Test detects memory problems linked to Alzheimer’s long before typical diagnosis, raising possibility of earlier drug intervention

A three-minute brainwave test can detect memory problems linked to Alzheimer’s disease long before people are typically diagnosed, raising hopes that the approach could help identify those most likely to benefit from new drugs for the condition.

In a small trial, the test flagged specific memory issues in people with mild cognitive impairment, highlighting who was at greater risk of developing Alzheimer’s. Trials in larger groups are under way.

Campaigners say only 82 sites have been fully examined and classified as contaminated, so scale of threat not known

Research from Friends of the Earth Cymru has found that at least 45,000 sites across Wales could be contaminated with toxic waste but have never been adequately inspected, leaving communities and wildlife vulnerable to a potential environmental crisis.

Despite Wales’s extensive industrial history, Tuesday’s publication found that due to a lack of funding and oversight, only 82 sites across the country have ever been fully examined and classified as contaminated, meaning the actual scale of the threat is unknown.

Protests denounce Trump administration’s policies and call for the protection of social safety nets

As Labor Day rallies took place across the US, the Chicago mayor Brandon Johnson sharply denounced the Trump administration’s threat to deploy federal troops to the city as part of an immigration crackdown.

“No federal troops in the city of Chicago,” said Johnson on Monday to a gathered crowd at the “Workers over Billionaires” demonstration in Chicago’s West Loop neighborhood.

• £30m Italian was surplus to requirements in Paris

• €14m fee agreed for Ederson’s departure to Turkey

Manchester City have agreed to buy goalkeeper Gianluigi Donnarumma from Paris Saint-Germain for about £30m (€35m). The move paves the way for Ederson to move to Fenerbahce for £12.1m (€14m).

Donnarumma has been deemed surplus to requirements by Luis Enrique at PSG, who signed Lucas Chevalier last month to be first choice at the European champions.

Former NYC mayor was sanctioned by courts and disbarred for amplifying false claims about the 2020 election

Donald Trump said Monday he will award Rudy Giuliani the Presidential Medal of Freedom, the nation’s highest civilian honor, two days after his longtime political ally was seriously injured in a car crash.

The decision places the award on a man once lauded for leading New York after the September 11, 2001, attacks and later sanctioned by courts and disbarred for amplifying false claims about the 2020 US presidential election. Giuliani, the former New York mayor, was also criminally charged in two states; he has denied wrongdoing.

• Four-times grand-slam champion wins 6-3, 6-2

• Osaka has always won title after reaching last eight

Naomi Osaka turned back the clock on Monday in New York, producing the cleanest big‑stage performance of her comeback from maternity leave to overwhelm Coco Gauff 6-3, 6-2 in a blockbuster fourth-round meeting inside Arthur Ashe Stadium.

In front of a packed 23,771-seat arena, the two crossover stars – who between them own three of the past seven US Open championships – reprised a rivalry that began with their famous encounter here in 2019. This time there were no tears, no consolations, only the sight of a four‑times major champion dictating terms again on the sport’s biggest stage.

When a cleaner starts working for a wealthy woman, she gets sucked in by a luxury mansion bursting with secrets. Get the popcorn ready for a preposterous world of locked rooms, creepy gardeners … and bodies

The writer Matthew Barry and director Ashley Way gave us one of the highlights of 2023’s television output in Men Up, a witty, moving, compassionate treat of a drama about the development of the drug that would become known as Viagra and the group of Welshmen who were among its first guinea pigs.

Their new offering is a more straightforward one, and if it doesn’t achieve the same success Men Up did, they can hardly be condemned for having set their bar so high.

• Isak signs six-year contract and ‘wants to create history’

• Deal for Crystal Palace’s Marc Guéhi falls through

Liverpool broke the British transfer record to sign Alexander Isak for £125m from Newcastle on deadline day but were foiled in an attempt to end a stunning window with a deal for Marc Guéhi.

On a contrasting day for the Premier League champions, Isak underwent a medical on Merseyside before signing a six-year contract worth around £300,000 a week. Liverpool also stepped up efforts to sign the Crystal Palace captain, Guéhi, who had a medical in London in anticipation of joining Arne Slot’s side after Steve Parish, the Palace chair, accepted £35m plus £5m in add-ons for the defender.

Leaders of Russia, Iran and North Korea will be at event marking 80 years since defeat of Japan in second world war

• Why are Putin and Kim at China’s Victory Day parade?

Leaders from countries united in their opposition to the west will gather in Beijing this week in a show of support for China’s president, Xi Jinping, at a second world war commemoration parade designed to show off China’s military strength and geopolitical might.

Described by western analysts as “the axis of upheaval”, the military, economic and political collaboration between Russia, China, Iran and North Korea has been on display on the battlefield in Ukraine and in the Middle East this year.

As the internet’s apex predator, zoomers are terrified of being seen as anything but a specific type of curated cool. It’s time they learned to live, laugh, love

Millennials are a generation infamous for their love of avocado toast, craft beer, Harry Potter, inventing the idea of a Disney adult and girlboss feminism. For that they’ve been subject to the brunt of our zeitgeist’s wrath in the years since.

Resentful boomers began the anti-millennial crusade. That’s to be expected; older people griping about the kids is nothing new, but rather a rite of passage that signifies a healthy ecosystem within the age groups. Hell, even gen X occasionally joins in on the action.

• Deadline day deal sheet was submitted for centre-back

• Glasner was so unhappy there were fears he could leave

Crystal Palace dramatically pulled the plug on Marc Guéhi’s move to Liverpool minutes before the transfer deadline because they couldn’t find an adequate replacement, despite agreeing to sell the England defender for £35m earlier in the day.

It is understood that Guéhi had been booked in to complete the first part of his medical in expectation of his move to Anfield going through, with a deal sheet having been submitted before Monday’s 7pm deadline. But despite Palace confirming the signing of the France Under-20 defender Jaydee Canvot from Toulouse for £21m, they decided not to sanction Guéhi’s departure at the last minute because they failed to bring in another more experienced option.

A murder investigation was launched Sunday after apparent homicide as authorities ask public for help

Nevada sheriffs are asking the public’s help in identifying a man killed on Saturday in an apparent homicide at the Burning Man festival.

In a statement on Monday, Pershing county sheriff Jerry Allen asked for assistance to identify the man, who was found dead in the futurist encampment of Black Rock City as the festival reaching its climax when an effigy – the eponymous burning man – was set alight.

Prime minister brings in chancellor’s deputy and former Bank of England chief to newly created senior roles

• Downing Street shake-up: who’s in and who’s out at No 10

Keir Starmer has attempted to wrest back control of economic policy from the Treasury by bolstering his No 10 team, bringing in the chancellor’s deputy and a former Bank of England chief to senior roles.

Before what is likely to be a tumultuous autumn for the government, he created two new roles with Darren Jones put in charge of day-to-day delivery and Minouche Shafik appointed the prime minister’s chief economic adviser.

Former pro wrestler Johnson takes on the role of man-mountain Kerr who goes into meltdown when the unthinkable happens – he loses

Benny Safdie has written and directed a solid bro drama for the UFC fanbase and maybe a little way beyond. It is about the central crisis in the life of man-mountain Mark Kerr, America’s pioneering MMA and ultimate fighting champ, who in 1997 found himself in the ring, or maybe the cage, with his demons after the unthinkable humiliation of losing for the first time.

This feature is in fact developed from a 2002 documentary about Kerr with the same title. He confronted his substance abuse, relationship anxieties and the question of what the heck life is for if you can’t simply win all the time. Kerr is played by Dwayne Johnson, a colossus of muscle topped off with a head the size of Indiana Jones’s boulder, a body on which the only visible fat is rippling at the nape of his neck. Johnson’s appearance is modified by close-cut frizzy hair and facial prosthetics that make him look like Jon Favreau playing the Hulk. No other casting was remotely possible – not unless Timothée Chalamet fancied bulking up. (Sacha Baron Cohen could do it these days, and would probably want to play it every bit as seriously and non-satirically as Johnson.)

Swiss multinational finds Laurent Freixe breached code of conduct as it names Philipp Navratil as his replacement

Nestlé has dismissed its chief executive, Laurent Freixe, after an investigation into an “undisclosed romantic relationship” with a subordinate that was found to have breached its code of business conduct.

The Swiss-headquartered multinational named Philipp Navratil as his replacement.

NHS equips all centres with life-saving software that will increase number of patients avoiding serious disability

Half of all people who experience a stroke in England will now recover thanks to a revolutionary AI scanning system that increases the number of patients avoiding serious disability.

The NHS has equipped every stroke centre in England with life-saving software that quickly tells doctors if they need to perform emergency surgery and can triple the rate of recovery.

The White House wanted India to bow. Instead, Narendra Modi flew to China, shook Xi Jinping’s hand and left Washington sidelined

Donald Trump’s imperial tendencies see the US president wield tariffs and sanctions in the expectation that America will receive tributes. Yet his latest move – punishing India with 50% tariffs for Russian oil purchases once encouraged by the US – has produced not submission but spectacle. It has sent India’s Narendra Modi to China for the first time in seven years as Xi Jinping hosted more than 20 leaders for the Shanghai Cooperation Organisation (SCO) summit in Tianjin. And it is in Tianjin, not Washington, where it looks as if the hinge of history is moving.

The SCO is easy to dismiss: the bloc is a bundle of contradictions. India and Pakistan remain adversaries. China and India still stare across a garrisoned Himalayan frontier, though relations have thawed since last October’s border breakthrough. Russia and China vie for influence in Central Asia. Unlike Nato, the SCO has no binding defence commitments. For much of its life, it has looked like a paper tiger, sending out communiques that were all roar and no bite.

Announcement comes a day after a US federal judge halted the deportation of 10 unaccompanied Guatemalan minors

Guatemala is ready and willing to receive about 150 unaccompanied children of all ages each week from the United States, the country’s president has said, a day after a US federal judge halted the deportation of 10 Guatemalan children.

Those children had already boarded a plane when a court responded to an emergency appeal on Sunday. They were later returned to the custody of the Office of Refugee Resettlement.

Home secretary under fire over suspension of family reunion system that she said was at risk of being exploited

Yvette Cooper has been accused of pushing children “into the arms of people smugglers” after halting a scheme allowing refugees to bring their families to the UK.

The home secretary said the refugee family reunion route was at risk of being exploited and she would temporarily suspend new applications until tougher rules were introduced next year.

Reforms to family reunion routes would be introduced to the Commons next month and become law in the spring.

The first returns of rejected asylum seekers to France under a “one in, one out” deal would take place this month.

She would set up a new independent body to process a backlog of immigration and asylum appeals.

Prospectus proposes forced displacement of entire population and puts territory into US trusteeship

A plan circulating in the White House to develop the “Gaza Riviera” as a string of high-tech megacities has been dismissed as an “insane” attempt to provide cover for the large-scale ethnic cleansing of the Palestinian territory’s population.

On Sunday the Washington Post published a leaked prospectus for the plan, which would involve the forced displacement of Gaza’s entire population of 2 million people and put the territory into a US trusteeship for at least a decade.

Labour and Lib Dems ask Tory leader to clarify details of alleged offer after former admissions staff dispute account

Labour and the Liberal Democrats have called for Kemi Badenoch to come clean about her claims of an offer from Stanford University at the age of 16, after former admissions staff said she had described an impossible scenario.

The Labour MP Peter Prinsley has written to the Conservatives leader saying she should lay out the specifics of how the alleged offer came about, given the doubts cast over her story. The Lib Dem education spokesperson, Munira Wilson, said Badenoch risked undermining trust.

• World Boxing wants competitors to take test

• Khelif won Olympic welterweight gold in Paris

Imane Khelif has appealed to the court of arbitration for sport over World Boxing’s decision to bar the 26-year-old from its events without a preliminary genetic sex test.

A court statement said an appeal was filed by Khelif on 5 August seeking to overturn a decision by World Boxing blocking the Algerian’s participation in the Box Cup in Eindhoven or any World Boxing event until a genetic sex test had taken place.

The small, proud Madrid club are back in Europe this season but playing against a backdrop of a civil war

The drunk, the brainless and the idle enjoyed this. They had said they wouldn’t sing, but the best nights aren’t planned they just happen, and in the end it was their kind of night. Chaotic, wild, a lot wrong but alright, like a picture of who they are, sticking it to the man up here and down there. Packed into crumbling, filthy stands, Rayo Vallecano’s fans didn’t see their team get a deserved victory against Barcelona on Sunday but on a torn-up, dried-out pitch with not much grass, in a ground where VAR became the latest thing to fail, they did watch them fight and do it their way too, flying into the team with a budget 18 times bigger as if they weren’t big at all. “Fantastic,” Hansi Flick called them.

It started as a protest and never stopped being one but it became something else too, something fun; they had been infuriated, worn down over years, and then they had been insulted but they couldn’t help but enjoy themselves, protest and party in one. Three days after Rayo had definitively qualified for the Conference League the team that is not just in the neighbourhood but of the neighbourhood almost comically incongruous in Europe, Rayo’s supporters announced they were going on strike. Rayo’s players meanwhile laid into the treble winners, worthy of more than the 1-1 draw it finished. But for a Lamine Yamal penalty which the broken video assistant system couldn’t correct, they might have got it. But for goalkeeper Joan García they definitely might.

Secondary share sale boosts fintech’s value by two-thirds but IPO timing remains unclear

Revolut employees are in line for a payout bonanza after the UK fintech firm launched a share sale that has pushed its valuation up by two-thirds to $75bn (£55bn).

The secondary sale, which prices each share at $1,381.06, will secure the finance app’s position as one of the world’s most valuable fintech firms.