Particle and nuclear physics evokes evokes images of huge accelerators probing the extremes of matter. But in this round-up of my favourite research of 2025 I have chosen five stories in which particle and nuclear physics forms the basis for a range of quirky and fascinating research from astrophysics to archaeology.

CERN experiment sheds light on missing blazar radiation

My first pick involves simulating the vast cosmic plasma in the lab. Blazars are extremely bright galaxies that are powered by supermassive black holes. They emit intense jets of radiation, including teraelectronvolt gamma rays – which can be detected by astronomers if a jet happens to point at Earth. As these high-energy photons travel through intergalactic space, they interact with background starlight, producing numerous electron–positron pairs. These pairs should, in theory, generate gigaelectronvolt gamma rays – but this secondary radiation has never been observed. One explanation is that intergalactic magnetic fields deflect these pairs and the resulting gamma rays away from our line of sight. However, there is no conclusive evidence for such fields. Another theory is that plasma instabilities in the sparse intergalactic medium could dissipate the energy of the pair beams. Now, physicists working on the Fireball experiment at CERN have simulated the effect of plasma instabilities by firing a beam of electron–positron pairs through a metre-long argon plasma. They found that plasma instabilities are too weak to account for the missing gamma radiation – strengthening the case for the existence of primordial intergalactic magnetic fields.

Portable source could produce high-energy muon beams

A compact source of muons could soon be discovering hidden chambers in ancient pyramids. Muons are subatomic particles similar to electrons but 200 times heavier. They are produced in copious amounts in the atmosphere by cosmic rays. These cosmic muons can penetrate long distances into materials and are finding increasing use in “muon tomography” – a technique that has imaged the interiors of huge objects such as volcanoes, pyramids and nuclear reactors. One downside of muon tomography is that muons are always vertically incident, limiting opportunities for imaging. While beams of muons can be made in accelerators, these are large and expensive facilities – and the direction of such beams are also fixed. Now, physicists at Lawrence Berkeley National Laboratory have demonstrated a compact, and potentially portable method for generating high-energy muon beams using laser plasma acceleration. It uses an ultra-intense, tightly focused laser pulse to accelerate electrons in a short plasma channel. These electrons then strike a metal target creating a muon beam. With more work, compact and portable muon sources could be developed, leading to new possibilities for non-destructive imaging in archaeology, geology, and nuclear safety.

Radioactive BEC could be a ‘superradiant neutrino laser’

Could a “superradiant neutrino laser” be created using radioactive atoms in an ultracold Bose–Einstein condensate (BEC)? The answer is “maybe”, according to theoretical work by two physicists in the US. Their proposal involves creating a BEC of rubidium-83, which undergoes beta decay involving the emission of neutrinos. Unlike photons, neutrinos are fermions and therefore cannot form the basis of conventional laser. However, if the atoms in the BEC are close enough together, quantum interactions between the atomic nuclei could accelerate beta decay and create a coherent, laser-like burst of neutrinos. This is a well-known phenomenon called superradiance. While the idea could be tested using existing technologies for making BECs, it would be a challenge to deploy radioactive rubidium in a conventional atomic physics lab. Another drawback is that there are no obvious applications for a neutrino laser – at least for now. However, the very idea of a neutrino laser is so cool that I am hoping that someone will try to build one soon!

Antimatter could be transported by road

If you happen to be driving between Geneva and Dusseldorf in the future, you might just overtake a shipment of antimatter. It will be on its way to an experiment that could solve some of the biggest mysteries in physics – including why there is much more matter than antimatter in the universe. While antielectrons (positrons) can be created in a small lab, antiprotons can only be created at large and expensive accelerators. This limits where antimatter experiments can be done. But now, physicists on the BASE collaboration at CERN have shown that it should be possible to transport antiprotons by road. Protons stood in for antiprotons in their demonstration and the particles were held in an electromagnetic trap at cryogenic temperatures and ultralow pressure. By transporting their BASE-STEP system around CERN’s Meyrin site, they showed it was stable and robust enough to handle the rigors of road travel.  The system will now be re-configured to transport antiprotons about 700 km to Germany’s Heinrich Heine University. There, physicists hope to search for charge–parity–time (CPT) violations in protons and antiprotons with a precision at least 100 times higher than is currently possible at CERN. The BASE collaboration is also cited in our Top 10 Breakthroughs of 2025 for their quantum control of a single antiproton.

Solid-state nuclear clock ticks ever closer

Solid quartz crystals revolutionized time keeping in the 20th century, so could solid-state nuclear clocks soon do the same? Today, the best timekeepers use the light emitted in atomic transitions. In principle, even better clocks could be made using very-low-energy gamma-rays emitted in some nuclear transitions. Nuclei are much smaller than atoms and these transitions are governed by the strong force. This means that such nuclear clocks would be far less susceptible to performance-degrading electromagnetic noise. And unlike atomic clocks, the nuclei could be embedded in solids – which would greatly simplify clock design. Thorium-229 shows great promise as a clock nucleus but it has two practical shortcomings: it is radioactive and extremely expensive. The solution to both of these problems is a clock design that uses only a tiny amount of thorium-229. Now researchers in the US have shown that physical vapour deposition can used to create extremely thin films of thorium tetrafluoride. Characterization using a vacuum ultraviolet laser confirmed the accessibility of the clock transition – but its lifetime was shorter and the signal less intense than measured in thorium-doped crystals. However, the researchers believe that these unexpected results should not dissuade those aiming to build nuclear clocks.

 

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There’s only a few days left in the International Year of Quantum Science and Technology, but we’re still finding plenty to celebrate here at Physics World HQ thanks to a long list of groundbreaking work by quantum physicists in 2025. Here are a few of our favourite stories from the past 12 months.

Observing negative time in atom-photon interactions

By this point in 2025, “negative time” may sound like the answer to the question “How long have I got left to buy holiday presents for my loved ones?” Earlier in the year, though, physicists led by experimentalist Aephraim Steinberg of the University of Toronto, Canada and theorist Howard Wiseman of Griffith University in Australia showed that the concept can also describe the average amount of time a photon spends in an excited atomic state. While experts have cautioned against interpreting “negative time” too literally – we aren’t in time machine territory here – it does seem like there’s something interesting going on in this system of ultracold rubidium atoms.

Creating an operating system for quantum networks

It is a truth universally acknowledged that any sufficiently advanced technology must be in want of a simple system to operate it. In April, the quantum world passed this milestone thanks to Stephanie Wehner and colleagues at Delft University of Technology in the Netherlands. Their operating system is called QNodeOS, and they developed it with the aim of improving access to quantum computing for the 99.99999% percent of people who aren’t (and mostly don’t need to be) intimately familiar with how quantum information processors work. Another advantage of QNodeOS is that it makes it easier for classical and quantum machines (and quantum devices built with different qbit architectures) to communicate with each other.

Pushing the boundary between the quantum and classical worlds

How big does an object have to be before it stops being quantum and starts behaving like the billiard-ball-like solids familiar from introductory classical mechanics courses? It’s a question that featured in our annual “Breakthrough of the Year” back in 2021, when two independent teams demonstrated quantum entanglement in pairs of 10-micron drumheads, and we’re returning to it this year in a different system: levitated nanoparticles around 100 nm in diameter.

In one boundary-pushing experiment, Massimiliano Rossi and colleagues at ETH Zurich, Switzerland and the Institute of Photonic Sciences in Barcelona, Spain cooled silica nanoparticles enough to extend their wave-like behaviour to 73 pm. In another study, Kiyotaka Aikawa and colleagues at the University of Tokyo, Japan performed the first quantum mechanical squeezing on a nanoparticle, narrowing its velocity distribution at the expense of its momentum distribution. We may not know exactly where the quantum-classical boundary is yet, but the list of quantum behaviours we’ve observed in usually-not-quantum objects keeps getting longer.

Using a quantum computer to generate quantum random numbers

What’s the best way to generate random numbers? In part, the answer depends on how random those numbers really need to be. For many applications, the pseudorandom numbers generated by classical computers, or the random-but-with-systematic-biases numbers found in, say, radio static, are good enough. But if you really, really need those numbers to be random, you need a quantum source – and thanks to work published this year by Scott Aaronson, Shi-Han Hung, Marco Pistoia and colleagues, that quantum source can now be a quantum computer. Which is a neat way of tying things together, don’t you think?

Giving Schrödinger’s cats a nuclear option

Finally, we would be remiss not to mention the work of Andrea Morello and colleagues at the University of New South Wales, Australia. This year, they became the first to create quantum superpositions known as a Schrödinger’s cat states in a heavy atom, antimony, that has a large nuclear spin. They also created what is certainly the year’s best scientific team photo, posing with cats on their laps and deadpan expressions more usually associated with too-cool-for-school indie musicians.

So congratulations to them, and to all the other teams in this list, for setting the bar high in a year that offered plenty for the quantum community to celebrate. We hope you enjoyed the International Year of Quantum Science and Technology, and we look forward to many more exciting discoveries in 2026.

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This year saw Physics World report on a raft of innovative and exciting developments in the worlds of medical physics and biotech. These included novel cancer therapies using low-temperature plasma or laser ablation, intriguing new devices such as biodegradable bone screws and a pacemaker smaller than a grain of rice, and neural engineering breakthroughs including an ultrathin bioelectric implant that improves movement in rats with spinal cord injuries and a tiny brain sensor that enables thought control of external devices. Here are a few more research highlights that caught my eye.

Vision transformed

One remarkable device introduced in 2025 was an eye implant that restored vision to patients with incurable sight loss. In a clinical study headed up at the University of Bonn, participants with sight loss due to age-related macular degeneration had a tiny wireless implant inserted under their retina. Used in combination with specialized glasses, the system restored the ability to read in 27 of 32 participants followed up a year later.

We also described a contact lens that enables wearers to see near-infrared light without night vision goggles, reported on an fascinating retinal stimulation technique that enabled volunteers to see colours never before seen by the human eye, and chatted with researchers in Hungary about how a tiny dissolvable eye insert they are developing could help astronauts suffering from eye conditions.

Radiation therapy advances

2025 saw several firsts in the field of radiation therapy. Researchers in Germany performed the first cancer treatment using a radioactive carbon ion beam, on a mouse with a bone tumour close to the spine. And a team at the Trento Proton Therapy Centre in Italy delivered the first clinical treatments using proton arc therapy – a development that made it onto our top 10 Breakthroughs of the Year.

Meanwhile, the ASTRO meeting saw Leo Cancer Care introduce its first upright photon therapy system, called Grace, which will deliver X-ray radiation to patients in an upright position. This new take on radiation delivery is also under investigation by a team at RaySearch Laboratories, who showed that combining static arcs and shoot-through beams could increase plan quality and reduce delivery times in upright proton therapy.

Among other new developments, there’s a low-cost, dual-robot radiotherapy system built by a team in Canada and targeted for use in low-resource settings, a study from Australia showing that combining microbeam radiation therapy with targeted radiosensitizers can optimize brain cancer treatment, and an investigation at Moffitt Cancer Center examining how skin luminance imaging improves Cherenkov-based radiotherapy dosimetry.

The impact of AI

It’s particularly interesting to examine how the rapid evolution of artificial intelligence (AI) is impacting healthcare, especially considering its potential for use in data-intensive tasks. Earlier this year, a team at Northwestern Medicine integrated a generative AI tool into a live clinical workflow for the first time, using it to draft radiology reports on X-ray images. In routine use, the AI model increased documentation efficiency by an average of 15.5%, while maintaining diagnostic accuracy.

Other promising applications include identifying hidden heart disease from electrocardiogram traces, contouring targets for brachytherapy treatment planning and detecting abnormalities in blood smear samples.

When introducing AI into the clinic, however, it’s essential that any AI-driven software is accurate, safe and trustworthy. To help assess these factors, a multinational research team identified potential pitfalls in the evaluation of algorithmic bias in AI radiology models, suggesting best practices to mitigate such bias.

A quantum focus

Finally, with 2025 being the International Year of Quantum Science and Technology, Physics World examined how quantum physics looks set to play a key role in medicine and healthcare. Many quantum-based companies and institutions are already working in the healthcare sector, with quantum sensors, in particular, close to being commercialized. As detailed in this feature on quantum sensing, such technologies are being applied for applications ranging from lab and point-of-care diagnostics to consumer wearables for medical monitoring, body scanning and microscopy.

Alongside, scientists at Jagiellonian University are applying quantum entanglement to cancer diagnostics and developing the world’s first whole-body quantum PET scanner, while researchers at the University of Warwick have created an ultrasensitive magnetometer based on nitrogen-vacancy centres in diamond that could detect small cancer metastases via keyhole surgery. There’s even a team designing a protein qubit that can be produced directly inside living cells and used as a magnetic field sensor (which also featured in this year’s top 10 breakthroughs).

And in September, we ran a Physics World Live event examining how quantum optics, quantum sensors and quantum entanglement can enable advanced disease diagnostics and transform medical imaging. The recording is available to watch here.

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