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Quantum physics guides proton motion in biological systems

If you dig deep enough, you’ll find that most biochemical and physiological processes rely on shuttling hydrogen atoms – protons – around living systems. Until recently, this proton transfer process was thought to occur when protons jump from water molecule to water molecule and between chains of amino acids. In 2023, however, researchers suggested that protons might, in fact, transfer at the same time as electrons. Scientists in Israel have now confirmed this is indeed the case, while also showing that proton movement is linked to the electrons’ spin, or magnetic moment. Since the properties of electron spin are defined by quantum mechanics, the new findings imply that essential life processes are intrinsically quantum in nature.

The scientists obtained this result by placing crystals of lysozyme – an enzyme commonly found in living organisms – on a magnetic substrate. Depending on the direction of the substrate’s magnetization, the spin of the electrons ejected from this substrate may be up or down. Once the electrons are ejected from the substrate, they enter the lysozymes. There, they become coupled to phonons, or vibrations of the crystal lattice.

Crucially, this coupling is not random. Instead, the chirality, or “handedness”, of the phonons determines which electron spin they will couple with – a  property known as chiral induced spin selectivity.

Excited chiral phonons mediate electron coupling spin

When the scientists turned their attention to proton transfer through the lysozymes, they discovered that the protons moved much more slowly with one magnetization direction than they did with the opposite. This connection between proton transfer and spin-selective electron transfer did not surprise Yossi Paltiel, who co-led the study with his Hebrew University of Jerusalem (HUJI) colleagues Naama Goren, Nir Keren and Oded Livnah in collaboration with Nurit Ashkenazy of Ben Gurion University and Ron Naaman of the Weizmann Institute.

“Proton transfer in living organisms occurs in a chiral environment and is an essential process,” Paltiel says. “Since protons also have spin, it was logical for us to try to relate proton transfer to electron spin in this work.”

The finding could shed light on proton hopping in biological environments, Paltiel tells Physics World. “It may ultimately help us understand how information and energy are transferred inside living cells, and perhaps even allow us to control this transfer in the future.

“The results also emphasize the role of chirality in biological processes,” he adds, “and show how quantum physics and biochemistry are fundamentally related.”

The HUJI team now plans to study how the coupling between the proton transfer process and the transfer of spin polarized electrons depends on specific biological environments. “We also want to find out to what extent the coupling affects the activity of cells,” Paltiel says.

Their present study is detailed in PNAS.

The post Quantum physics guides proton motion in biological systems appeared first on Physics World.

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Development and application of a 3-electrode setup for the operando detection of side reactions in Li-Ion batteries

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Join us to learn about the development and application of a 3-Electrode setup for the operando detection of side reactions in Li-Ion batteries.

Detecting parasitic side reactions originating both from the cathode active materials (CAMs) and the electrolyte is paramount for developing more stable cell chemistries for Li-ion batteries. This talk will present a method for the qualitative analysis of oxidative electrolyte oxidation, as well as the quantification of released lattice oxygen and transition metal ions (TM ions) from the CAM. It is based on a 3-electrode cell design employing a Vulcan carbon-based sense electrode (SE) that is held at a controlled voltage against a partially delithiated lithium iron phosphate (LFP) counter electrode (CE). At this SE, reductive currents can be measured while polarizing a CAM or carbon working electrode (WE) against the same LFP CE. In voltametric scans, we show how the SE potential can be selected to specifically detect a given side reaction during CAM charge/discharge, allowing, e.g., to discriminate between lattice oxygen, protons, and dissolved TMs. Furthermore, it is shown via On-line Electrochemical Mass Spectrometry (OEMS) that O2 reduction in the here-used LP47 electrolyte consumes ~2.3 electrons/O2. Using this value, the lattice oxygen release deduced from the 3-electrode setup upon charging of the NCA WE is in good agreement with OEMS measurements up to NCA potentials >4.65 VLi. At higher potentials, the contributions from the reduction of TM ions can be quantified by comparing the integrated SE current with the O2 evolution from OEMS

Lennart Reuter headshot
Lennart Reuter

Lennart Reuter is a PhD student in the group of Prof Hubert A Gasteiger at the Chair of Technical Electrochemistry at TUM. His research focused on the interfacial processes in lithium-ion batteries that govern calendar life, cycle stability, and rate capability. He advanced the on-line electrochemical mass spectrometry (OEMS) technique to investigate gas evolution mechanisms from interfacial side reactions at the cathode and anode. His work also explored how SEI formation and graphite structural changes affect Li⁺ transport, using impedance spectroscopy and complementary analysis techniques.

 

Leonhard J Reinschluessel headshot
Leonhard J Reinschluessel

Leonhard J Reinschluessel is currently a PhD candidate at at the Chair of Technical Electrochemistry in the Gasteiger research group at the Technical University of Munich (TUM). His current work encompasses an in-depth understanding of the complex interplay of cathode- and electrolyte degradation mechanisms in lithium-ion batteries using operando lab-based and synchrotron techniques. He received his MSc in chemistry from TUM, where he investigated the mitigation of aging of FeNC-based cathode catalyst layers in PEMFCs in his thesis at the Gasteiger group Electrochemistry at TUM. His research focused on the interfacial processes in lithium-ion batteries that govern calendar life, cycle stability, and rate capability. He advanced the on-line electrochemical mass spectrometry (OEMS) technique to investigate gas evolution mechanisms from interfacial side reactions at the cathode and anode. His work also explored how SEI formation and graphite structural changes affect Li⁺ transport, using impedance spectroscopy and complementary analysis techniques.

The post Development and application of a 3-electrode setup for the operando detection of side reactions in Li-Ion batteries appeared first on Physics World.

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People benefit from medicine, but machines need healthcare too

I began my career in the 1990s at a university spin-out company, working for a business that developed vibration sensors to monitor the condition of helicopter powertrains and rotating machinery. It was a job that led to a career developing technologies and techniques for checking the “health” of machines, such as planes, trains and trucks.

What a difference three decades has made. When I started out, we would deploy bespoke systems that generated limited amounts of data. These days, everything has gone digital and there’s almost more information than we can handle. We’re also seeing a growing use of machine learning and artificial intelligence (AI) to track how machines operate.

In fact, with AI being increasingly used in medical science – for example to predict a patient’s risk of heart attacks – I’ve noticed intriguing similarities between how we monitor the health of machines and the health of human bodies. Jet engines and hearts are very different objects, but in both cases monitoring devices gives us a set of digitized physical measurements.

A healthy perspective

Sensors installed on a machine provide various basic physical parameters, such as its temperature, pressure, flow rate or speed. More sophisticated devices can yield information about, say, its vibration, acoustic behaviour, or (for an engine) oil debris or quality. Bespoke sensors might even be added if an important or otherwise unchecked aspect of a machine’s performance needs to be monitored – provided the benefits of doing so outweigh the cost.

Generally speaking, the sensors you use in a particular situation depend on what’s worked before and whether you can exploit other measurements, such as those controlling the machine. But whatever sensors are used, the raw data then have to be processed and manipulated to extract particular features and characteristics.

If the machine appears to be going wrong, can you try to diagnose what the problem might be?

Once you’ve done all that, you can then determine the health of the machine, rather like in medicine. Is it performing normally? Does it seem to be developing a fault? If the machine appears to be going wrong, can you try to diagnose what the problem might be?

Generally, we do this by tracking a range of parameters to look for consistent behaviour, such as a steady increase, or by seeing if a parameter exceeds a pre-defined threshold. With further analysis, we can also try to predict the future state of the machine, work out what its remaining useful life might be, or decide if any maintenance needs scheduling.

A diagnosis typically involves linking various anomalous physical parameters (or symptoms) to a probable cause. As machines obey the laws of physics, a diagnosis can either be based on engineering knowledge or be driven by data – or sometimes the two together. If a concrete diagnosis can’t be made, you can still get a sense of where a problem might lie before carrying out further investigation or doing a detailed inspection.

One way of doing this is to use a “borescope” – essentially a long, flexible cable with a camera on the end. Rather like an endoscope in medicine, it allows you to look down narrow or difficult-to-reach cavities. But unlike medical imaging, which generally takes place in the controlled environment of a lab or clinic, machine data are typically acquired “in the field”. The resulting images can be tricky to interpret because the light is poor, the measurements are inconsistent, or the equipment hasn’t been used in the most effective way.

Even though it can be hard to work out what you’re seeing, in-situ visual inspections are vital as they provide evidence of a known condition, which can be directly linked to physical sensor measurements. It’s a kind of health status calibration. But if you want to get more robust results, it’s worth turning to advanced modelling techniques, such as deep neural networks.

One way to predict the wear and tear of a machine’s constituent parts is to use what’s known as a “digital twin”. Essentially a virtual replica of a physical object, a digital twin is created by building a detailed model and then feeding in real-time information from sensors and inspections. The twin basically mirrors the behaviour, characteristics and performance of the real object.

Real-time monitoring

Real-time health data are great because they allow machines to be serviced as and when required, rather than following a rigid maintenance schedule. For example, if a machine has been deployed heavily in a difficult environment, it can be serviced sooner, potentially preventing an unexpected failure. Conversely, if it’s been used relatively lightly and not shown any problems, then  maintenance could be postponed or reduced in scope. This saves time and money because the equipment will be out of action less than anticipated.

We can work out which parts will need repairing or replacing, when the maintenance will be required and who will do it

Having information about a machine’s condition at any point in time not only allows this kind of “intelligent maintenance” but also lets us use associated resources wisely. For example, we can work out which parts will need repairing or replacing, when the maintenance will be required and who will do it. Spare parts can therefore be ordered only when required, saving money and optimizing supply chains.

Real-time health-monitoring data are particularly useful for companies owning many machines of one kind, such as airlines with a fleet of planes or haulage companies with a lot of trucks. It gives them a better understanding not just of how machines behave individually – but also collectively to give a “fleet-wide” view. Noticing and diagnosing failures from data becomes an iterative process, helping manufacturers create new or improved machine designs.

This all sounds great, but in some respects, it’s harder to understand a machine than a human. People can be taken to hospitals or clinics for a medical scan, but a wind turbine or jet engine, say, can’t be readily accessed, switched off or sent for treatment. Machines also can’t tell us exactly how they feel.

However, even humans don’t always know when there’s something wrong. That’s why it’s worth us taking a leaf from industry’s book and consider getting regular health monitoring and checks. There are lots of brilliant apps out there to monitor and track your heart rate, blood pressure, physical activity and sugar levels.

Just as with a machine, you can avoid unexpected failure, reduce your maintenance costs, and make yourself more efficient and reliable. You could, potentially, even live longer too.

The post People benefit from medicine, but machines need healthcare too appeared first on Physics World.

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Japan’s ispace suffers second lunar landing failure

The Japanese firm ispace has suffered another setback after its second attempt to land on the Moon ended in failure yesterday. The Hakuto-R Mission 2, also known as Resilience, failed to touch down near the centre of Mare Frigoris (sea of cold) in the far north of the Moon after a sensor malfunctioned during descent.

Launched on 15 January from the Kennedy Space Center, Florida, aboard a SpaceX Falcon 9 rocket, the craft spent four months travelling to the Moon before it entered lunar orbit on 7 May. It then spent the past month completing several lunar orbital manoeuvres.

During the descent phase, the 2.3 m-high lander began a landing sequence that involved firing its main propulsion system to gradually decelerate and adjust its attitude. ispace says that the lander was confirmed to be nearly vertical but then the company lost communication with the craft.

The firm concludes that the laser rangefinder experienced delays attempting to measure the distance to the lunar surface during descent, meaning that it was unable to decelerate sufficiently to carry out a soft landing.

“Given that there is currently no prospect of a successful lunar landing, our top priority is to swiftly analyze the telemetry data we have obtained thus far and work diligently to identify the cause,” noted ispace founder and chief executive officer Takeshi Hakamada in a statement. “We strive to restore trust by providing a report of the findings.”

The mission was planned to have operated for about two weeks. Resilience featured several commercial payloads, worth $16m, including a food-production experiment and a deep-space radiation probe. It also carried a rover, dubbed Tenacious, which was about the size of a microwave oven and would have collected and analyzed lunar regolith.

The rover would have also delivered a Swedish artwork called The Moonhouse – a small red cottage with white corners – and placed it at a “symbolically meaningful” site on the Moon.

Lunar losses

The company’s first attempt to land on the Moon also ended in failure in 2023 when the Hakuto-R Mission 1 crashed landed despite being in a vertical position as it carried out the final approach to the lunar surface.

The issue was put down to a software problem that incorrectly assessed the craft’s altitude during descent.

If the latest attempt was a success, ispace would have joined the US firms Intuitive Machines and Firefly Aerospace that both successfully landed on the Moon last year and in March, respectively.

The second lunar loss also casts doubt on ispace’s plans for further lunar landings with the grand aim of establishing a lunar colony of 1000 inhabitants by the 2040s.

The post Japan’s ispace suffers second lunar landing failure appeared first on Physics World.

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Richard Bond and George Efstathiou: meet the astrophysicists who are shaping our understanding of the early universe

This episode of the Physics World Weekly podcast features George Efstathiou and Richard Bond, who share the 2025 Shaw Prize in Astronomy, “for their pioneering research in cosmology, in particular for their studies of fluctuations in the cosmic microwave background (CMB). Their predictions have been verified by an armada of ground-, balloon- and space-based instruments, leading to precise determinations of the age, geometry, and mass-energy content of the universe.”

Bond and Efstathiou talk about how the CMB emerged when the universe was just 380,000 years old and explain how the CMB is observed today. They explain why studying fluctuations in today’s CMB provides a window into the nature of the universe as it existed long ago, and how future studies could help physicists understand the nature of dark matter – which is one of the greatest mysteries in physics.

Efstathiou is emeritus professor of astrophysics at the University of Cambridge in the UK – and Richard Bond is a professor at the Canadian Institute for Theoretical Astrophysics (CITA) and university professor at the University of Toronto in Canada. Bond and Efstathiou share the 2025 Shaw Prize in Astronomy and its $1.2m prize money equally.

This podcast is sponsored by The Shaw Prize Foundation.

The post Richard Bond and George Efstathiou: meet the astrophysicists who are shaping our understanding of the early universe appeared first on Physics World.

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