Physicist, molecular biologist, neuroscientist: Francis Crick’s scientific career took many turns. And now, he is the subject of zoologist Matthew Cobb’s new book, Crick: a Mind in Motion – from DNA to the Brain.
Born in 1916, Crick studied physics at University College London in the mid-1930s, before working for the Admiralty Research Laboratory during the Second World War. But after reading physicist Erwin Schrödinger’s 1944 book What Is Life? The Physical Aspect of the Living Cell, and a 1946 article on the structure of biological molecules by chemist Linus Pauling, Crick left his career in physics and switched to molecular biology in 1947.
Six years later, while working at the University of Cambridge, he played a key role in decoding the double-helix structure of DNA, working in collaboration with biologist James Watson, biophysicist Maurice Wilkins and other researchers including chemist and X-ray crystallographer Rosalind Franklin. Crick, alongside Watson and Wilkins, went on to receive the 1962 Nobel Prize in Physiology and Medicine for the discovery.
Finally, Crick’s career took one more turn in the mid-1970s. After experiencing a mental health crisis, Crick left Britain and moved to California. He took up neuroscience in an attempt to understand the roots of human consciousness, as discussed in his 1994 book, The Astonishing Hypothesis: the Scientific Search for the Soul.
Parallel lives
When he died in 2004, Crick’s office wall at Salk Institute in La Jolla, US, carried portraits of Charles Darwin and Albert Einstein, as Cobb notes on the final page of his deeply researched and intellectually fascinating biography. But curiously, there is not a single other reference to Einstein in Cobb’s massive book. Furthermore, there is no reference at all to Einstein in the equally large 2009 biography of Crick, Francis Crick: Hunter of Life’s Secrets, by historian of science Robert Olby, who – unlike Cobb – knew Crick personally.
Nevertheless, a comparison of Crick and Einstein is illuminating. Crick’s family background (in the shoe industry), and his childhood and youth are in some ways reminiscent of Einstein’s. Both physicists came from provincial business families of limited financial success, with some interest in science yet little intellectual distinction. Both did moderately well at school and college, but were not academic stars. And both were exposed to established religion, but rejected it in their teens; they had little intrinsic respect for authority, without being open rebels until later in life.
The similarities continue into adulthood, with the two men following unconventional early scientific careers. Both of them were extroverts who loved to debate ideas with fellow scientists (at times devastatingly), although they were equally capable of long, solitary periods of concentration throughout their careers. In middle age, they migrated from their home countries – Germany (Einstein) and Britain (Crick) – to take up academic positions in the US, where they were much admired and inspiring to other scientists, but failed to match their earlier scientific achievements.
In their personal lives, both Crick and Einstein had a complicated history with women. Having divorced their first wives, they had a variety of extramarital affairs – as discussed by Cobb without revealing the names of these women – while remaining married to their second wives. Interestingly, Crick’s second wife, Odile Crick (whom he was married to for 55 years) was an artist, and drew the famous schematic drawing of the double helix published in Nature in 1953.
Stories of friendships
Although Cobb misses this fascinating comparison with Einstein, many other vivid stories light up his book. For example, he recounts Watson’s claim that just after their success with DNA in 1953, “Francis winged into the Eagle [their local pub in Cambridge] to tell everyone within hearing distance that we had found the secret of life” – a story that later appeared on a plaque outside the pub.
“Francis always denied he said anything of the sort,” notes Cobb, “and in 2016, at a celebration of the centenary of Crick’s birth, Watson publicly admitted that he had made it up for dramatic effect (a few years earlier, he had confessed as much to Kindra Crick, Francis’s granddaughter).” No wonder Watson’s much-read 1968 book The Double Helix caused a furious reaction from Crick and a temporary breakdown in their friendship, as Cobb dissects in excoriating detail.
Watson’s deprecatory comments on Franklin helped to provoke the current widespread belief that Crick and Watson succeeded by stealing Franklin’s data. After an extensive analysis of the available evidence, however, Cobb argues that the data was willingly shared with them by Franklin, but that they should have formally asked her permission to use it in their published work – “Ambition, or thoughtlessness, stayed their hand.”
In fact, it seems Crick and Franklin were friends in 1953, and remained so – with Franklin asking Crick for his advice on her draft scientific papers – until her premature death from ovarian cancer in 1958. Indeed, after her first surgery in 1956, Franklin went to stay with Crick and his wife at their house in Cambridge, and then returned to them after her second operation. There certainly appears to be no breakdown in trust between the two. When Crick was nominated for the Nobel prize in 1961, he openly stated, “The data which really helped us obtain the structure was mainly obtained by Rosalind Franklin.”
As for Crick’s later study of consciousness, Cobb comments, “It would be easy to dismiss Crick’s switch to studying the brain as the quixotic project of an ageing scientist who did not know his limits. After all, he did not make any decisive breakthrough in understanding the brain – nothing like the double helix… But then again, nobody else did, in Crick’s lifetime or since.” One is perhaps reminded once again of Einstein, and his preoccupation during later life with his unified field theory, which remains an open line of research today.
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