In United States v. Skrmetti, the Supreme Court ruled that Tennessee’s ban on gender-affirming care for minors was not unconstitutional—the first case of its kind on which the court has ruled.
In 1962, the world stood on the brink of nuclear war during the Cuban Missile Crisis. What saved us wasn’t just luck — it was the hotline hastily established between […]
Astronomers at the European Southern Observatory’s Very Large Telescope (VLT) have created a thousand colour image of the nearby Sculptor Galaxy.
First discovered by Carloine Herschel in 1783 the spiral galaxy lies 11 million light-years away and is one of the brightest galaxies in the sky.
While conventional images contain only a handful of colours, this new map contains thousands, which helps astronomers to understand the age, composition and motion of the stars, gas and dust within it.
To create the image, researchers observed the galaxy for over 50 hours with the Multi Unit Spectroscopic Explorer (MUSE) instrument on the VLT, which is based at the Paranal Observatory in Chile’s Atacama Desert.
The team then stitched together over 100 exposures to cover an area of the galaxy about 65 000 light-years wide.
The image revealed around 500 planetary nebulae – regions of gas and dust cast off from dying Sun-like stars – that can be used as distance markers to their host galaxies.
“Galaxies are incredibly complex systems that we are still struggling to understand,” notes astronomer Enrico Congiu, lead author of the study. “The Sculptor Galaxy is in a sweet spot – it is close enough that we can resolve its internal structure and study its building blocks with incredible detail, but at the same time, big enough that we can still see it as a whole system.”
Future work will involve understanding how gas flows, changes its composition, and forms stars in the galaxy. “How such small processes can have such a big impact on a galaxy whose entire size is thousands of times bigger is still a mystery,” adds Congiu.
The Shape of Wonder: How Scientists Think, Work and Live
By Alan Lightman and Martin Rees
In their delightful new book, cosmologist Martin Rees and physicist and science writer Alan Lightman seek to provide “an honest picture of scientists as people and how they work and think”. The Shape of Wonder does this by exploring the nature of science, examining the role of critical thinking, and looking at how scientific theories are created and revised as new evidence emerges. It also includes profiles of individual scientists, ranging from historical Nobel-prize winners such as physicist Werner Heisenberg and biologist Barbara McClintock, to rising stars like CERN theorist Dorota Grabowska. Matin Durrani
2025 Pantheon Books
Our Accidental Universe: Stories of Discovery from Asteroids to Aliens By Chris Lintott
TV presenter and physics professor Chris Lintott brings all his charm and wit to his new book Our Accidental Universe. He looks at astronomy through the lens of the human errors and accidents that lead to new knowledge. It’s a loose theme that allows him to skip from the search for alien life to pulsars and the Hubble Space Telescope. Lintott has visited many of the facilities he discusses, and spoken to many people working in these areas, adding a personal touch to his stated aim of elucidating how science really gets done. Kate Gardner
2024 Penguin
Science is Lit: Awesome Electricity and Mad Magnets By Big Manny (Emanuel Wallace)
Want to feed your child’s curiosity about how things work (and don’t mind creating a mini lab in your house)? Take a look at Awesome Electricity and Mad Magnets, the second in the Science is Lit series by Emanuel Wallace – aka TikTok star “Big Manny”. Wallace introduces four key concepts of physics – force, sound, light and electricity – in an enthusiastic and fun way that’s accessible for 8–12 year olds. With instructions for experiments kids can do at home, and a clear explanation of the scientific process, your child can really experience what it’s like to be a scientist. Sarah Tesh
2025 Puffin
NASA art This concept painting by Robert McCall shows a telescope in a hypothetical lunar observatory, sheltered from the Sun to protect its lens. (Courtesy: Robert McCall)
Space Posters & Paintings: Art About NASA By Bill Schwartz
Astronomy is the most visually gifted of all the sciences, with endless stunning photographs of our cosmos. But perhaps what sets NASA apart from other space agencies is its art programme, which has existed since 1962. In Space Posters and Paintings: Art about NASA, documentary filmmaker Bill Schwartz has curated a striking collection of nostalgic artworks that paint the history of NASA and its various missions across the solar system and beyond. Particularly captivating are pioneering artist Robert McCall’s paintings of the Gemini and Apollo missions. This large-format coffee book is a perfect purchase for any astronomy buff. Tushna Commissariat
Venturi Space, a company working with Astrolab on lunar rover concepts, unveiled an all-European rover design it hopes to offer to European space agencies.
Three European aerospace companies expect to decide by next month whether to combine their space divisions, something that could still take years to win regulatory approvals.
A team of researchers have discovered a case of severe osteomyelitis in a Plateosaurus found in Switzerland’s Frick Valley – and you can see it in person.
The Trump administration’s proposal would cut electro-optical imagery funding and eliminate funding entirely for the acquisition of synthetic aperture radar (SAR) imagery
New Mexico, June 17, 2025 — Desert Works Propulsion (DWP) has successfully completed initial testing of multiple prototype discharge and neutralizer cathodes developed for Turion Space Corp.’s TIE-20 ion thruster. […]
The administration of US president Donald Trump has proposed drastic cuts to science that would have severe consequence for physics and astronomy if passed by the US Congress. The proposal could involve the cancellation of one of the twin US-based gravitational-wave detectors as well as the axing of a proposed next-generation ground-based telescope and a suite of planned NASA mission. Scientific societies, groups of scientists and individuals have expressed their shock over the scale of the reductions.
In the budget request, which represents the start of the budgeting procedure for the year from 1 October, the National Science Foundation (NSF) would see its funding plummet from $9bn to just$3.9bn – imperilling several significant projects. While the NSF had hoped to support both next-generation ground-based telescopes planned by the agency – the Giant Magellan Telescope (GMT) and the Thirty Meter Telescope (TMT) – the new budget would only allow one to be supported.
On 12 June the GMT, which is already 40% completed thanks to private funds, received NSF approval confirming that the observatory will advance into its “major facilities final design phase”, one of the final steps before becoming eligible for federal construction funding. The TMT, meanwhile, which is set to be built in Hawaii, has been hit with delays following protests over adding more telescopes to Mauna Kea. In a statement from the TMT International Observatory, it said it was “disappointed that the NSF’s current budget proposal does not include TMT”.
It is also possible that one of the twin Laser Interferometer Gravitational-Wave Observatory (LIGO) facilities – one in Hanford, Washington and the other in Livingston, Louisiana – would have to close down after the budget proposes a 39.6% cut to LIGO operations. Having one LIGO facility would significantly cut its ability to identify and localize events that produce gravitational waves.
“This level of cut, if enacted, would drastically reduce the science coming out of LIGO and have long-term negative consequences for gravitational-wave astrophysics,” notes LIGO executive director David Reitze. LIGO officials told Physics World that the cuts would be “extremely punishing to US gravitational wave science” and would mean “layoffs to staff, reduced scientific output, and the loss of scientific leadership in a field that made first detections just under 10 years ago”.
NASA’s science funding, meanwhile, would reduce by 47% year on year, and the agency as a whole would see more than 5500 staff lose their jobs as its workforce gets slashed from 17 391 to just 11 853. NASA would also lose planned missions to Venus, Mars, Jupiter and the asteroid Apophis that will pass close to Earth in 2029. Several scientific missions focusing on planet Earth, meanwhile, would also be axed.
The American Astronomical Society expressed “grave concern” that the cuts to NASA and the NSF “would result in an historic decline of American investment in basic scientific research”. The Planetary Society called the proposed NASA budget “an extinction-level event for the space agency’s most productive, successful and broadly supported activity”. Before the cuts were announced, the Trump administration pulled its nomination of billionaire industrialist Jared Isaacman for NASA administrator after his supporter Elon Musk left his post as head of the “Department of Government Efficiency.”
‘The elephant in the room’
The Department of Energy, meanwhile, will receive a slight increase in its defence-related budget, from the current $34.0bn to next year’s proposed $33.8bn. But its non-defence budget will fall by 26% from $16.83bn to $12.48bn. Michael Kratsios, Trump’s science adviser and head of the White House Office of Science and Technology Policy, sought to justify the administration’s planned cuts in a meeting at the National Academy of Sciences (NAS) on 19 May.
“Spending more money on the wrong things is far worse than spending less money on the right things,” Kratsios noted, adding that the country had received “diminishing returns” on its investments in science over the past four decades and that it now requires “new methods and approaches to supporting research”. He also suggested that research now undertaken at US universities falls short of what he called “gold standard science”, citing “political biases [that] have displaced the vital search for truth”. Universities, he stated, have lost public trust because they have “promoted diversity, equity and inclusion”.
The US science community, however, is unconvinced. “The elephant in the room right now is whether the drastic reductions in research budgets and new research policies across the federal agencies will allow us to remain a research and development powerhouse,” says Marcia McNutt, president of the National Academy of Sciences. “Thus, we are embarking on a radical new experiment in what conditions promote science leadership – with the US being the ‘treatment’ group, and China as the control.”
Former presidential science adviser Neal Lane, now at Rice University, told Physics World that while the US administration appears to value some aspects of scientific research such as AI, quantum, nuclear and biotechnologies, it “doesn’t seem to understand or acknowledge that technological advances and innovation often come from basic research in unlikely fields of science“. He expects the science community to “continue to push back” by writing and visiting members of Congress, many of whom support science, and “by speaking out to the public and encouraging various organizations to do that same”.
Indeed, an open letter by the group Stand Up for Science dated 26 May calls the administration’s stated commitment to “gold standard science” an approach “that will actually undermine scientific rigor and the transparent progress of science”. It would “introduce stifling limits on intellectual freedom in our nation’s laboratories and federal funding agencies”, the letter adds.
As of 13 June, the letter had more than 9250 signatures. Another letter, sent to Jay Bhattachayra, director of the National Institutes of Health (NIH), from some 350 NIH members, almost 100 of whom identified themselves, asserted that they “remain pressured to implement harmful measures” such as halting clinical trials midstream. In the budget request, the NIH would lose about 40%, leaving it with $27.5bn next year. The administration also plans to consolidate the NIH’s 27 institutes into just eight.
A political divide
On the day that the budget was announced, 16 states run by Democratic governors called on a federal court to block cuts in programmes and funding for the NSF. They point out that universities in their states could lose significant income if the cuts go ahead. In fact, the administration’s budget proposal is just that: a proposal. Congress will almost certainly make changes to it before presenting it to Trump for his signature. And while Republicans in the Senate and House of Representatives find it difficult to oppose the administration, science has historically enjoyed support by both Democrats and Republicans.
Despite that, scientists are gearing up for a difficult summer of speculation about financial support. “We are gaming matters at the moment because we are looking at the next budget cycle,” says Peter Littlewood, chair of the University of Chicago’s physics department. “The principal issues now are to bridge postdocs and graduating PhD students, who are in limbo because offers are drying up.” Littlewood says that, while alternative sources of funding such as philanthropic contributions can help, if the proposed government cuts are approved then philanthropy can’t replace federal support. “I’m less worried about whether this or that piece of research gets done than in stabilizing the pipeline, so all our discussions centre around that,” adds Littlewood.
Lane fears the cuts will put people off from careers in science, even in the unlikely event that all the cuts get reversed. “The combination of statements by the president and other administrative officials do considerable harm by discouraging young people born in the US and other parts of the world from pursuing their education and careers in [science] in America,” he says. “That’s a loss for all Americans.”
Astronomers in China have observed a pulsar that becomes partially eclipsed by an orbiting companion star every few hours. This type of observation is very rare and could shed new light on how binary star systems evolve.
While most stars in our galaxy exist in pairs, the way these binary systems form and evolve is still little understood. According to current theories, when two stars orbit each other, one of them may expand so much that its atmosphere becomes large enough to encompass the other. During this “envelope” phase, mass can be transferred from one star to the other, causing the stars’ orbit to shrink over a period of around 1000 years. After this, the stars either merge or the envelope is ejected.
In the special case where one star in the pair is a neutron star, the envelope-ejection scenario should, in theory, produce a helium star that has been “stripped” of much of its material and a “recycled” millisecond pulsar – that is, a rapidly spinning neutron star that flashes radio pulses hundreds of times per second. In this type of binary system, the helium star can periodically eclipse the pulsar as it orbits around it, blocking its radio pulses and preventing us from detecting them here on Earth. Only a few examples of such a binary system have ever been observed, however, and all previous ones were in nearby dwarf galaxies called the Magellanic Clouds, rather than our own Milky Way.
The researchers used FAST to observe this suspected binary system at radio frequencies ranging from 1.0 to 1.5 GHz over a period of four and a half years. They fitted the times that the radio pulses arrived at the telescope with a binary orbit model to show that the system has an eccentricity of less than 3 × 10−5. This suggests that the pulsar and its companion star are in a nearly circular orbit. The diameter of this orbit, Han points out, is smaller than that of our own Sun, and its period – that is, the time it takes the two stars to circle each other – is correspondingly short, at 3.6 hours. For a sixth of this time, the companion star blocks the pulsar’s radio signals.
The team also found that the rate at which this orbital period is changing (the so-called spin period derivative) is unusually high for a millisecond-period pulsar, at 3.63 × 10−18 s s−1 .This shows that energy is rapidly being lost from the system as the pulsar spins down.
“We knew that PSR J1928+1815 was special from November 2021 onwards,” says Han. “Once we’d accumulated data with FAST, one of my students, ZongLin Yang, studied the evolution of such binaries in general and completed the timing calculations from the data we had obtained for this system. His results suggested the existence of the helium star companion and everything then fell into place.”
Short-lived phenomenon
This is the first time a short-life (107 years) binary consisting of a neutron star and a helium star has ever been detected, Han tells Physics World. “It is a product of the common envelope evolution that lasted for only 1000 years and that we couldn’t observe directly,” he says.
“Our new observation is the smoking gun for long-standing binary star evolution theories, such as those that describe how stars exchange mass and shrink their orbits, how the neutron star spins up by accreting matter from its companion and how the shared hydrogen envelope is ejected.”
The system could help astronomers study how neutron stars accrete matter and then cool down, he adds. “The binary detected in this work will evolve to become a system of two compact stars that will eventually merge and become a future source of gravitational waves.”
Full details of the study are reported in Science.
European startup The Exploration Company, which is developing a cargo vehicle with a key test flight launching within days, says it has long-term plans to fly people as well.
As the world celebrates the 2025 International Year of Quantum Science and Technology, it’s natural that we should focus on the exciting applications of quantum physics in computing, communication and cryptography. But quantum physics is also set to have a huge impact on medicine and healthcare. Quantum sensors, in particular, can help us to study the human body and improve medical diagnosis – in fact, several systems are close to being commercialized.
Quantum computers, meanwhile, could one day help us to discover new drugs by providing representations of atomic structures with greater accuracy and by speeding up calculations to identify potential drug reactions. But what other technologies and projects are out there? How can we forge new applications of quantum physics in healthcare and how can we help discover new potential use cases for the technology?
Those are the some of the questions tackled in a recent report, on which this Physics World article is based, published by Innovate UK in October 2024. Entitled Quantum for Life, the report aims to kickstart new collaborations by raising awareness of what quantum physics can do for the healthcare sector. While the report says quite a bit about quantum computing and quantum networking, this article will focus on quantum sensors, which are closer to being deployed.
Sense about sensors
The importance of quantum science to healthcare isn’t new. In fact, when a group of academics and government representatives gathered at Chicheley Hall back in 2013 to hatch plans for the UK’s National Quantum Technologies Programme, healthcare was one of the main applications they identified. The resulting £1bn programme, which co-ordinated the UK’s quantum-research efforts, was recently renewed for another decade and – once again – healthcare is a key part of the remit.
As it happens, most major hospitals already use quantum sensors in the form of magnetic resonance imaging (MRI) machines. Pioneered in the 1970s, these devices manipulate the quantum spin states of hydrogen atoms using magnetic fields and radio waves. By measuring how long those states take to relax, MRI can image soft tissues, such as the brain, and is now a vital part of the modern medicine toolkit.
While an MRI machine measures the quantum properties of atoms, the sensor itself is classical, essentially consisting of electromagnetic coils that detect the magnetic flux produced when atomic spins change direction. More recently, though, we’ve seen a new generation of nanoscale quantum sensors that are sensitive enough to detect magnetic fields emitted by a target biological system. Others, meanwhile, consist of just a single atom and can monitor small changes in the environment.
There are lots of different quantum-based companies and institutions working in the healthcare sector
As the Quantum for Life report shows, there are lots of different quantum-based companies and institutions working in the healthcare sector. There are also many promising types of quantum sensors, which use photons, electrons or spin defects within a material, typically diamond. But ultimately what matters is what quantum sensors can achieve in a medical environment.
Quantum diagnosis
While compiling the report, it became clear that quantum-sensor technologies for healthcare come in five broad categories. The first is what the report labels “lab diagnostics”, in which trained staff use quantum sensors to observe what is going on inside the human body. By monitoring everything from our internal temperature to the composition of cells, the sensors can help to identify diseases such as cancer.
Currently, the only way to definitively diagnose cancer is to take a sample of cells – a biopsy – and examine them under a microscope in a laboratory. Biopsies are often done with visual light but that can damage a sample, making diagnosis tricky. Another option is to use infrared radiation. By monitoring the specific wavelengths the cells absorb, the compounds in a sample can be identified, allowing molecular changes linked with cancer to be tracked.
Unfortunately, it can be hard to differentiate these signals from background noise. What’s more, infrared cameras are much more expensive than those operating in the visible region. One possible solution is being explored by Digistain, a company that was spun out of Imperial College, London, in 2019. It is developing a product called EntangleCam that uses two entangled photons – one infrared and one visible (figure 1).
a One way in which quantum physics is benefiting healthcare is through entangled photons created by passing laser light through a nonlinear crystal (left). Each laser photon gets converted into two lower-energy photons – one visible, one infrared – in a process called spontaneous parametric down conversion. In technology pioneered by the UK company Digistain, the infrared photon can be sent through a sample, with the visible photon picked up by a detector. As the photons are entangled, the visible photon gives information about the infrared photon and the presence of, say, cancer cells. b Shown here are cells seen with traditional stained biopsy (left) and with Digistain’s method (right).
If the infrared photon is absorbed by, say, a breast cancer cell, that immediately affects the visible photon with which it is entangled. So by measuring the visible light, which can be done with a cheap, efficient detector, you can get information about the infrared photon – and hence the presence of a potential cancer cell (Phys. Rev.108 032613). The technique could therefore allow cancer to be quickly diagnosed before a tumour has built up, although an oncologist would still be needed to identify the area for the technique to be applied.
Point of care
The second promising application of quantum sensors lies in “point-of-care” diagnostics. We all became familiar with the concept during the COVID-19 pandemic when lateral-flow tests proved to be a vital part of the worldwide response to the virus. The tests could be taken anywhere and were quick, simple, reliable and relatively cheap. Something that had originally been designed to be used in a lab was now available to most people at home.
Quantum technology could let us miniaturize such tests further and make them more accurate, such that they could be used at hospitals, doctor’s surgeries or even at home. At the moment, biological indicators of disease tend to be measured by tagging molecules with fluorescent markers and measuring where, when and how much light they emit. But because some molecules are naturally fluorescent, those measurements have to be processed to eliminate the background noise.
One emerging quantum-based alternative is to characterize biological samples by measuring their tiny magnetic fields. This can be done, for example, using diamond specially engineered with nitrogen-vacancy (NV) defects. Each is made by removing two carbon atoms from the lattice and implanting a nitrogen atom in one of the gaps, leaving a vacancy in the other. Behaving like an atom with discrete energy levels, each defect’s spin state is influenced by the local magnetic field and can be “read out” from the way it fluoresces.
One UK company working in this area is Element Six. It has joined forces with the US-based firm QDTI to make a single-crystal diamond-based device that can quickly identify biomarkers in blood plasma, cerebrospinal fluid and other samples extracted from the body. The device detects magnetic fields produced by specific proteins, which can help identify diseases in their early stages, including various cancers and neurodegenerative conditions like Alzheimer’s. Another firm using single-crystal diamond to detect cancer cells is Germany-based Quantum Total Analysis Systems (QTAS).
Matthew Markham, a physicist who is head of quantum technologies at Element Six, thinks that healthcare has been “a real turning point” for the company. “A few years ago, this work was mostly focused on academic problems,” he says. “But now we are seeing this technology being applied to real-world use cases and that it is transitioning into industry with devices being tested in the field.”
An alternative approach involves using tiny nanometre-sized diamond particles with NV centres, which have the advantage of being highly biocompatible. QT Sense of the Netherlands, for example, is using these nanodiamonds to build nano-MRI scanners that can measure the concentration of molecules that have an intrinsic magnetic field. This equipment has already been used by biomedical researchers to investigate single cells (figure 2).
2 Centre of attention
(Courtesy: Element Six)
A nitrogen-vacancy defect in diamond – known as an NV centre – is made by removing two carbon atoms from the lattice and implanting a nitrogen atom in one of the gaps, leaving a vacancy in the other. Using a pulse of green laser light, NV centres can be sent from their ground state to an excited state. If the laser is switched off, the defects return to their ground state, emitting a visible photon that can be detected. However, the rate at which the fluorescent light drops while the laser is off depends on the local magnetic field. As companies like Element Six and QTSense are discovering, NV centres in diamond are great way of measuring magnetic fields in the human body especially as the surrounding lattice of carbon atoms shields the NV centre from noise.
Australian firm FeBI Technologies, meanwhile, is developing a device that uses nanodiamonds to measure the magnetic properties of ferritin – a protein that stores iron in the body. The company claims its technology is nine orders of magnitude more sensitive than traditional MRI and will allow patients to monitor the amount of iron in their blood using a device that is accurate and cheap.
Wearable healthcare
The third area in which quantum technologies are benefiting healthcare is what’s billed in the Quantum for Life report as “consumer medical monitoring and wearable healthcare”. In other words, we’re talking about devices that allow people to monitor their health in daily life on an ongoing basis. Such technologies are particularly useful for people who have a diagnosed medical condition, such as diabetes or high blood pressure.
NIQS Tech, for example, was spun off from the University of Leeds in 2022 and is developing a highly accurate, non-invasive sensor for measuring glucose levels. Traditional glucose-monitoring devices are painful and invasive because they basically involve sticking a needle in the body. While newer devices use light-based spectroscopic measurements, they tend to be less effective for patients with darker skin tones.
The sensor from NIQS Tech instead uses a doped silica platform, which enables quantum interference effects. When placed in contact with the skin and illuminated with laser light, the device fluoresces, with the lifetime of the fluorescence depending on the amount of glucose in the user’s blood, regardless of skin tone. NIQS has already demonstrated proof of concept with lab-based testing and now wants to shrink the technology to create a wearable device that monitors glucose levels continuously.
Body imaging
The fourth application of quantum tech lies in body scanning, which allows patients to be diagnosed without needing a biopsy. One company leading in this area is Cerca Magnetics, which was spun off from the University of Nottingham. In 2023 it won the inaugural qBIG prize for quantum innovation from the Institute of Physics, which publishes Physics World, for developing wearable optically pumped magnetometers for magnetoencephalography (MEG), which measure magnetic fields generated by neuronal firings in the brain. Its devices can be used to scan patients’ brains in a comfortable seated position and even while they are moving.
Quantum-based scanning techniques could also help diagnose breast cancer, which is usually done by exposing a patient’s breast tissue to low doses of X-rays. The trouble with such mammograms is that all breasts contain a mix of low-density fatty and other, higher-density tissue. The latter creates a “white blizzard” effect against the dark background, making it challenging to differentiate between healthy tissue and potential malignancies.
That’s a particular problem for the roughly 40% of women who have a higher concentration of higher-density tissue. One alternative is to use molecular breast imaging (MBI), which involves imaging the distribution of a radioactive tracer that has been intravenously injected into a patient. This tracer, however, exposes patients to a higher (albeit still safe) dose of radiation than with a mammogram, which means that patients have to be imaged for a long time to get enough signal.
A solution could lie with the UK-based firm Kromek, which is using cadmium zinc telluride (CZT) semiconductors that produce a measurable voltage pulse from just a single gamma-ray photon. As well as being very efficient over a broad range of X-ray and gamma-ray photon energies, CZTs can be integrated onto small chips operating at room temperature. Preliminary results with Kromek’s ultralow-dose and ultrafast detectors show they work with barely one-eighth of the amount of tracer as traditional MBI techniques.
Faster and better Breast cancer is often detected with X-rays using mammography but it can be tricky to spot tumours in areas where the breast tissue is dense. One alternative is molecular breast imaging (MBI), which uses a radioactive tracer to “light up” areas of cancer in the breast and works even in dense breast tissue. However, MBI currently exposes patients to more radiation than with mammography, which is where cadmium zinc telluride (CZT) semiconductors, developed by the UK firm Kromek, could help. They produce a measurable voltage pulse from just a single gamma-ray photon, opening the door for “ultralow-dose MBI” – where much clearer images are created with barely one-eighth of the radiation. (Courtesy: Kromek)
“Our prototypes have shown promising results,” says Alexander Cherlin, who is principal physicist at Kromek. The company is now designing and building a full-size prototype of the camera as part of Innovate UK’s £2.5m “ultralow-dose” MBI project, which runs until the end of 2025. It involves Kromek working with hospitals in Newcastle along with researchers at University College London and the University of Newcastle.
Microscopy matters
The final application of quantum sensors to medicine lies in microscopy, which these days no longer just means visible light but everything from Raman and two-photon microscopy to fluorescence lifetime imaging and multiphoton microscopy. These techniques allow samples to be imaged at different scales and speeds, but they are all reaching various technological limits.
Quantum technologies can help us break the technological limits of microscopy
Quantum technologies can help us break those limits. Researchers at the University of Glasgow, for example, are among those to have used pairs of entangled photons to enhance microscopy through “ghost imaging”. One photon in each pair interacts with a sample, with the image built up by detecting the effect on its entangled counterpart. The technique avoids the noise created when imaging with low levels of light (Sci. Adv. 6 eaay2652).
Researchers at the University of Strathclyde, meanwhile, have used nanodiamonds to get around the problem that dyes added to biological samples eventually stop fluorescing. Known as photobleaching, the effect prevents samples from being studied after a certain time (Roy. Soc. Op. Sci.6 190589). In the work, samples could be continually imaged and viewed using two-photon excitation microscopy with a 10-fold increase in resolution.
Looking to the future
But despite the great potential of quantum sensors in medicine, there are still big challenges before the technology can be deployed in real, clinical settings. Scalability – making devices reliably, cheaply and in sufficient numbers – is a particular problem. Fortunately, things are moving fast. Even since the Quantum for Life report came out late in 2024, we’ve seen new companies being founded to address these problems.
One such firm is Bristol-based RobQuant, which is developing solid-state semiconductor quantum sensors for non-invasive magnetic scanning of the brain. Such sensors, which can be built with the standard processing techniques used in consumer electronics, allow for scans on different parts of the body. RobQuant claims its sensors are robust and operate at ambient temperatures without requiring any heating or cooling.
Agnethe Seim Olsen, the company’s co-founder and chief technologist, believes that making quantum sensors robust and scalable is vital if they are to be widely adopted in healthcare. She thinks the UK is leading the way in the commercialization of such sensors and will benefit from the latest phase of the country’s quantum hubs. Bringing academia and businesses together, they include the £24m Q-BIOMED biomedical-sensing hub led by University College London and the £27.5m QuSIT hub in imaging and timing led by the University of Birmingham.
Q-BIOMED is, for example, planning to use both single-crystal diamond and nanodiamonds to develop and commercialize sensors that can diagnose and treat diseases such as cancer and Alzheimer’s at much earlier stages of their development. “These healthcare ambitions are not restricted to academia, with many startups around the globe developing diamond-based quantum technology,” says Markham at Element Six.
As with the previous phases of the hubs, allowing for further research encourages start-ups – researchers from the forerunner of the QuSIT hub, for example, set up Cerca Magnetics. The growing maturity of some of these quantum sensors will undoubtedly attract existing medical-technology companies. The next five years will be a busy and exciting time for the burgeoning use of quantum sensors in healthcare.
A new study reveals the key lies not in the production of a regrowth molecule, but in that molecule's controlled destruction. The discovery could inspire future regenerative medicine.
Connexion
