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US regulators approve new non-opioid drug to treat acute pain
Oral drug from Vertex, branded as Journavx, represents alternative to addictive opioids that have fueled US crisis
The US Food and Drug Administration approved a new drug to treat acute pain, the health regulator said on Thursday, offering a first-of-its-kind alternative to addictive opioid painkillers that have fueled a national crisis.
The Vertex Pharmaceuticals oral drug, branded Journavx, works by blocking pain signals at their source, unlike opioids, which trigger the brain’s reward centers as they travel through the blood and then attach to neural receptors, leading to addiction and abuse.
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FDA Approves Journavx Drug to Treat Pain Without Addiction Risk
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Premier League: 10 things to look out for this weekend
There’s a huge game at Bournemouth, a huge game at Arsenal and … er, a huge game at Portman Road
Nuno Espírito Santo said that at Bournemouth last weekend, where they were humbled 5-0, his Nottingham Forest side had been “not accurate and missed a lot of passes”. It is interesting that four of Forest’s last five – and five of their last eight – Premier League games rank in their bottom eight of the season on pass completion. “We have to perform much better,” he said. “We have to be more solid and play better football. We have so many things to improve.” Though results in that period, at least until last week, continued to be good they have relied on statistically unlikely displays of finishing prowess. Before their trip to Bournemouth, Forest had scored with nine of their previous 12 shots on target in all competitions and the last time a Chris Wood shot on target failed to go in was before Christmas. Both Nuno and Fabian Hürzeler were sent off for misconduct during a rancorous conclusion to the fixture between these sides at the Amex Stadium last September. Simon Burnton
Nottingham Forest v Brighton, Saturday 12.30pm (all times GMT)
Bournemouth v Liverpool, Saturday 3pm
Everton v Leicester, Saturday 3pm
Ipswich v Southampton, Saturday 3pm
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