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FLIR MIX – a breakthrough in infrared and visible imaging

23 avril 2025 à 16:25

FLIR MIX

Until now, researchers have had to choose between thermal and visible imaging: One reveals heat signatures while the other provides structural detail. Recording both and trying to align them manually — or harder still, synchronizing them temporally — can be inconsistent and time-consuming. The result is data that is close but never quite complete. The new FLIR MIX is a game changer, capturing and synchronizing high-speed thermal and visible imagery at up to 1000 fps. Visible and high-performance infrared cameras with FLIR Research Studio software work together to deliver one data set with perfect spatial and temporal alignment — no missed details or second guessing, just a complete picture of fast-moving events.

Jerry Beeney
Jerry Beeney

Jerry Beeney is a seasoned global business development leader with a proven track record of driving product growth and sales performance in the Teledyne FLIR Science and Automation verticals. With more than 20 years at Teledyne FLIR, he has played a pivotal role in launching new thermal imaging solutions, working closely with technical experts, product managers, and customers to align products with market demands and customer needs. Before assuming his current role, Beeney held a variety of technical and sales positions, including senior scientific segment engineer. In these roles, he managed strategic accounts and delivered training and product demonstrations for clients across diverse R&D and scientific research fields. Beeney’s dedication to achieving meaningful results and cultivating lasting client relationships remains a cornerstone of his professional approach.

The post FLIR MIX – a breakthrough in infrared and visible imaging appeared first on Physics World.

Why Resilient GPS (R-GPS) Matters for US Military Superiority: We Must Address GPS Vulnerabilities

17 avril 2025 à 13:00

GPS is not only a cornerstone to our military superiority, it is foundational to our national and global economic stability. In fact, analysts warn that GPS outages could cost our […]

The post Why Resilient GPS (R-GPS) Matters for US Military Superiority: We Must Address GPS Vulnerabilities appeared first on SpaceNews.

Radiosurgery made easy: the role of the Gamma Knife in modern radiotherapy

17 avril 2025 à 15:16

This podcast features Alonso Gutierrez, who is chief of medical physics at the Miami Cancer Institute in the US. In a wide-ranging conversation with Physics World’s Tami Freeman, Gutierrez talks about his experience using Elekta’s Leksell Gamma Knife for radiosurgery in a busy radiotherapy department.

This podcast is sponsored by Elekta.

The post Radiosurgery made easy: the role of the Gamma Knife in modern radiotherapy appeared first on Physics World.

On the path towards a quantum economy

16 avril 2025 à 16:15
The high-street bank HSBC has worked with the NQCC, hardware provider Rigetti and the Quantum Software Lab to investigate the advantages that quantum computing could offer for detecting the signs of fraud in transactional data. (Courtesy: Shutterstock/Westend61 on Offset)

Rapid technical innovation in quantum computing is expected to yield an array of hardware platforms that can run increasingly sophisticated algorithms. In the real world, however, such technical advances will remain little more than a curiosity if they are not adopted by businesses and the public sector to drive positive change. As a result, one key priority for the UK’s National Quantum Computing Centre (NQCC) has been to help companies and other organizations to gain an early understanding of the value that quantum computing can offer for improving performance and enhancing outcomes.

To meet that objective the NQCC has supported several feasibility studies that enable commercial organizations in the UK to work alongside quantum specialists to investigate specific use cases where quantum computing could have a significant impact within their industry. One prime example is a project involving the high-street bank HSBC, which has been exploring the potential of quantum technologies for spotting the signs of fraud in financial transactions. Such fraudulent activity, which affects millions of people every year, now accounts for about 40% of all criminal offences in the UK and in 2023 generated total losses of more than £2.3 bn across all sectors of the economy.

Banks like HSBC currently exploit classical machine learning to detect fraudulent transactions, but these techniques require a large computational overhead to train the models and deliver accurate results. Quantum specialists at the bank have therefore been working with the NQCC, along with hardware provider Rigetti and the Quantum Software Lab at the University of Edinburgh, to investigate the capabilities of quantum machine learning (QML) for identifying the tell-tale indicators of fraud.

“HSBC’s involvement in this project has brought transactional fraud detection into the realm of cutting-edge technology, demonstrating our commitment to pushing the boundaries of quantum-inspired solutions for near-term benefit,” comments Philip Intallura, Group Head of Quantum Technologies at HSBC. “Our philosophy is to innovate today while preparing for the quantum advantage of tomorrow.”

Another study focused on a key problem in the aviation industry that has a direct impact on fuel consumption and the amount of carbon emissions produced during a flight. In this logistical challenge, the aim was to find the optimal way to load cargo containers onto a commercial aircraft. One motivation was to maximize the amount of cargo that can be carried, the other was to balance the weight of the cargo to reduce drag and improve fuel efficiency.

“Even a small shift in the centre of gravity can have a big effect,” explains Salvatore Sinno of technology solutions company Unisys, who worked on the project along with applications engineers at the NQCC and mathematicians at the University of Newcastle. “On a Boeing 747 a displacement of just 75 cm can increase the carbon emissions on a flight of 10,000 miles by four tonnes, and also increases the fuel costs for the airline company.”

aeroplane being loaded with cargo
A hybrid quantum–classical solution has been used to optimize the configuration of air freight, which can improve fuel efficiency and lower carbon emissions. (Courtesy: Shutterstock/supakitswn)

With such a large number of possible loading combinations, classical computers cannot produce an exact solution for the optimal arrangement of cargo containers. In their project the team improved the precision of the solution by combining quantum annealing with high-performance computing, a hybrid approach that Unisys believes can offer immediate value for complex optimization problems. “We have reached the limit of what we can achieve with classical computing, and with this work we have shown the benefit of incorporating an element of quantum processing into our solution,” explains Sinno.

The HSBC project team also found that a hybrid quantum–classical solution could provide an immediate performance boost for detecting anomalous transactions. In this case, a quantum simulator running on a classical computer was used to run quantum algorithms for machine learning. “These simulators allow us to execute simple QML programmes, even though they can’t be run to the same level of complexity as we could achieve with a physical quantum processor,” explains Marco Paini, the project lead for Rigetti. “These simulations show the potential of these low-depth QML programmes for fraud detection in the near term.”

The team also simulated more complex QML approaches using a similar but smaller-scale problem, demonstrating a further improvement in performance. This outcome suggests that running deeper QML algorithms on a physical quantum processor could deliver an advantage for detecting anomalies in larger datasets, even though the hardware does not yet provide the performance needed to achieve reliable results. “This initiative not only showcases the near-term applicability of advanced fraud models, but it also equips us with the expertise to leverage QML methods as quantum computing scales,” comments Intellura.

Indeed, the results obtained so far have enabled the project partners to develop a roadmap that will guide their ongoing development work as the hardware matures. One key insight, for example, is that even a fault-tolerant quantum computer would struggle to process the huge financial datasets produced by a bank like HSBC, since a finite amount of time is needed to run the quantum calculation for each data point. “From the simulations we found that the hybrid quantum–classical solution produces more false positives than classical methods,” says Paini. “One approach we can explore would be to use the simulations to flag suspicious transactions and then run the deeper algorithms on a quantum processor to analyse the filtered results.”

This particular project also highlighted the need for agreed protocols to navigate the strict rules on data security within the banking sector. For this project the HSBC team was able to run the QML simulations on its existing computing infrastructure, avoiding the need to share sensitive financial data with external partners. In the longer term, however, banks will need reassurance that their customer information can be protected when processed using a quantum computer. Anticipating this need, the NQCC has already started to work with regulators such as the Financial Conduct Authority, which is exploring some of the key considerations around privacy and data security, with that initial work feeding into international initiatives that are starting to consider the regulatory frameworks for using quantum computing within the financial sector.

For the cargo-loading project, meanwhile, Sinno says that an important learning point has been the need to formulate the problem in a way that can be tackled by the current generation of quantum computers. In practical terms that means defining constraints that reduce the complexity of the problem, but that still reflect the requirements of the real-world scenario. “Working with the applications engineers at the NQCC has helped us to understand what is possible with today’s quantum hardware, and how to make the quantum algorithms more viable for our particular problem,” he says. “Participating in these studies is a great way to learn and has allowed us to start using these emerging quantum technologies without taking a huge risk.”

Indeed, one key feature of these feasibility studies is the opportunity they offer for different project partners to learn from each other. Each project includes an end-user organization with a deep knowledge of the problem, quantum specialists who understand the capabilities and limitations of present-day solutions, and academic experts who offer an insight into emerging theoretical approaches as well as methodologies for benchmarking the results. The domain knowledge provided by the end users is particularly important, says Paini, to guide ongoing development work within the quantum sector. “If we only focused on the hardware for the next few years, we might come up with a better technical solution but it might not address the right problem,” he says. “We need to know where quantum computing will be useful, and to find that convergence we need to develop the applications alongside the algorithms and the hardware.”

Another major outcome from these projects has been the ability to make new connections and identify opportunities for future collaborations. As a national facility NQCC has played an important role in providing networking opportunities that bring diverse stakeholders together, creating a community of end users and technology providers, and supporting project partners with an expert and independent view of emerging quantum technologies. The NQCC has also helped the project teams to share their results more widely, generating positive feedback from the wider community that has already sparked new ideas and interactions.

“We have been able to network with start-up companies and larger enterprise firms, and with the NQCC we are already working with them to develop some proof-of-concept projects,” says Sinno. “Having access to that wider network will be really important as we continue to develop our expertise and capability in quantum computing.”

The post On the path towards a quantum economy appeared first on Physics World.

Very high-energy electrons could prove optimal for FLASH radiotherapy

15 avril 2025 à 13:00

Electron therapy has long played an important role in cancer treatments. Electrons with energies of up to 20 MeV can treat superficial tumours while minimizing delivered dose to underlying tissues; they are also ideal for performing total skin therapy and intraoperative radiotherapy. The limited penetration depth of such low-energy electrons, however, limits the range of tumour sites that they can treat. And as photon-based radiotherapy technology continues to progress, electron therapy has somewhat fallen out of fashion.

That could all be about to change with the introduction of radiation treatments based on very high-energy electrons (VHEEs). Once realised in the clinic, VHEEs – with energies from 50 up to 400 MeV – will deliver highly penetrating, easily steerable, conformal treatment beams with the potential to enable emerging techniques such as FLASH radiotherapy. French medical technology company THERYQ is working to make this opportunity a reality.

Therapeutic electron beams are produced using radio frequency (RF) energy to accelerate electrons within a vacuum cavity. An accelerator of a just over 1 m in length can boost electrons to energies of about 25 MeV – corresponding to a tissue penetration depth of a few centimetres. It’s possible to create higher energy beams by simply daisy chaining additional vacuum chambers. But such systems soon become too large and impractical for clinical use.

THERYQ is focusing on a totally different approach to generating VHEE beams. “In an ideal case, these accelerators allow you to reach energy transfers of around 100 MeV/m,” explains THERYQ’s Sébastien Curtoni. “The challenge is to create a system that’s as compact as possible, closer to the footprint and cost of current radiotherapy machines.”

Working in collaboration with CERN, THERYQ is aiming to modify CERN’s Compact Linear Collider technology for clinical applications. “We are adapting the CERN technology, which was initially produced for particle physics experiments, to radiotherapy,” says Curtoni. “There are definitely things in this design that are very useful for us and other things that are difficult. At the moment, this is still in the design and conception phase; we are not there yet.”

VHEE advantages

The higher energy of VHEE beams provides sufficient penetration to treat deep tumours, with the dose peak region extending up to 20–30 cm in depth for parallel (non-divergent) beams using energy levels of 100–150 MeV (for field sizes of 10 x 10 cm or above). And in contrast to low-energy electrons, which have significant lateral spread, VHEE beams have extremely narrow penumbra with sharp beam edges that help to create highly conformal dose distributions.

“Electrons are extremely light particles and propagate through matter in very straight lines at very high energies,” Curtoni explains. “If you control the initial direction of the beam, you know that the patient will receive a very steep and well defined dose distribution and that, even for depths above 20 cm, the beam will remain sharp and not spread laterally.”

Electrons are also relatively insensitive to tissue inhomogeneities, such as those encountered as the treatment beam passes through different layers of muscle, bone, fat or air. “VHEEs have greater robustness against density variations and anatomical changes,” adds THERYQ’s Costanza Panaino. “This is a big advantage for treatments in locations where there is movement, such as the lung and pelvic areas.”

It’s also possible to manipulate VHEEs via electromagnetic scanning. Electrons have a charge-to-mass ratio roughly 1800 times higher than that of protons, meaning that they can be steered with a much weaker magnetic field than required for protons. “As a result, the technology that you are building has a smaller footprint and the possibility costing less,” Panaino explains. “This is extremely important because the cost of building a proton therapy facility is prohibitive for some countries.”

Enabling FLASH

In addition to expanding the range of clinical indications that can be treated with electrons, VHEE beams can also provide a tool to enable the emerging – and potentially game changing – technique known as FLASH radiotherapy. By delivering therapeutic radiation at ultrahigh dose rates (higher than 100 Gy/s), FLASH vastly reduces normal tissue toxicity while maintaining anti-tumour activity, potentially minimizing harmful side-effects.

The recent interest in the FLASH effect began back in 2014 with the report of a differential response between normal and tumour tissue in mice exposed to high dose-rate, low-energy electrons. Since then, most preclinical FLASH studies have used electron beams, as did the first patient treatment in 2019 – a skin cancer treatment at Lausanne University Hospital (CHUV) in Switzerland, performed with the Oriatron eRT6 prototype from PMB-Alcen, the French company from which THERYQ originated.

FLASH radiotherapy is currently being used in clinical trials with proton beams, as well as with low-energy electrons, where it remains intrinsically limited to superficial treatments. Treating deep-seated tumours with FLASH requires more highly penetrating beams. And while the most obvious option would be to use photons, it’s extremely difficult to produce an X-ray beam with a high enough dose rate to induce the FLASH effect without excessive heat generation destroying the conversion target.

“It’s easier to produce a high dose-rate electron beam for FLASH than trying to [perform FLASH] with X-rays, as you use the electron beam directly to treat the patient,” Curtoni explains. “The possibility to treat deep-seated tumours with high-energy electron beams compensates for the fact that you can’t use X-rays.”

Panaino points out that in addition to high dose rates, FLASH radiotherapy also relies on various interdependent parameters. “Ideally, to induce the FLASH effect, the beam should be pulsed at a frequency of about 100 Hz, the dose-per-pulse should be 1 Gy or above, and the dose rate within the pulse should be higher than 106 Gy/s,” she explains.

VHEE infographic

Into the clinic

THERYQ is using its VHEE expertise to develop a clinical FLASH radiotherapy system called FLASHDEEP, which will use electrons at energies of 100 to 200 MeV to treat tumours at depths of up to 20 cm. The first FLASHDEEP systems will be installed at CHUV (which is part of a consortium with CERN and THERYQ) and at the Gustave Roussy cancer centre in France.

“We are trying to introduce FLASH into the clinic, so we have a prototype FLASHKNiFE machine that allows us to perform low-energy, 6 and 9 MeV, electron therapy,” says Charlotte Robert, head of the medical physics department research group at Gustave Roussy. “The first clinical trials using low-energy electrons are all on skin tumours, aiming to show that we can safely decrease the number of treatment sessions.”

While these initial studies are limited to skin lesions, clinical implementation of the FLASHDEEP system will extend the benefits of FLASH to many more tumour sites. Robert predicts that VHEE-based FLASH will prove most valuable for treating radioresistant cancers that cannot currently be cured. The rationale is that FLASH’s ability to spare normal tissue will allow delivery of higher target doses without increasing toxicity.

“You will not use this technology for diseases that can already be cured, at least initially,” she explains. “The first clinical trial, I’m quite sure, will be either glioblastoma or pancreatic cancers that are not effectively controlled today. If we can show that VHEE FLASH can spare normal tissue more than conventional radiotherapy can, we hope this will have a positive impact on lesion response.”

“There are a lot of technological challenges around this technology and we are trying to tackle them all,” Curtoni concludes. “The ultimate goal is to produce a VHEE accelerator with a very compact beamline that makes this technology and FLASH a reality for a clinical environment.”

The post Very high-energy electrons could prove optimal for FLASH radiotherapy appeared first on Physics World.

Intercalation-based desalination and carbon capture for water and climate sustainability

14 avril 2025 à 10:28

webinar main image

With increased water scarcity and global warming looming, electrochemical technology offers low-energy mitigation pathways via desalination and carbon capture.  This webinar will demonstrate how the less than 5 molar solid-state concentration swings afforded by cation intercalation materials – used originally in rocking-chair batteries – can effect desalination using Faradaic deionization (FDI).  We show how the salt depletion/accumulation effect – that plagues Li-ion battery capacity under fast charging conditions – is exploited in a symmetric Na-ion battery to achieve seawater desalination, exceeding by an order of magnitude the limits of capacitive deionization with electric double layers.  While initial modeling that introduced such an architecture blazed the trail for the development of new and old intercalation materials in FDI, experimental demonstration of seawater-level desalination using Prussian blue analogs required cell engineering to overcome the performance-degrading processes that are unique to the cycling of intercalation electrodes in the presence of flow, leading to innovative embedded, micro-interdigitated flow fields with broader application toward fuel cells, flow batteries, and other flow-based electrochemical devices.  Similar symmetric FDI architectures using proton intercalation materials are also shown to facilitate direct-air capture of carbon dioxide with unprecedentedly low energy input by reversibly shifting pH within aqueous electrolyte.

Kyle Smith headshot
Kyle Smith

Kyle C Smith joined the faculty of Mechanical Science and Engineering at the University of Illinois Urbana-Champaign (UIUC) in 2014 after completing his PhD in mechanical engineering (Purdue, 2012) and his post-doc in materials science and engineering (MIT, 2014).  His group uses understanding of flow, transport, and thermodynamics in electrochemical devices and materials to innovate toward separations, energy storage, and conversion.  For his research he was awarded the 2018 ISE-Elsevier Prize in Applied Electrochemistry of the International Society of Electrochemistry and the 2024 Dean’s Award for Early Innovation as an associate professor by UIUC’s Grainger College.  Among his 59 journal papers and 14 patents and patents pending, his work that introduced Na-ion battery-based desalination using porous electrode theory [Smith and Dmello, J. Electrochem. Soc., 163, p. A530 (2016)] was among the top ten most downloaded in the Journal of the Electrochemical Society for five months in 2016.  His group was also the first to experimentally demonstrate seawater-level salt removal using this approach [Do et al., Energy Environ. Sci., 16, p. 3025 (2023); Rahman et al., Electrochimica Acta, 514, p. 145632 (2025)], introducing flow fields embedded in electrodes to do so.

The post Intercalation-based desalination and carbon capture for water and climate sustainability appeared first on Physics World.

Designer van der Waals materials for quantum optical emission

Join us for an insightful webinar highlighting cutting-edge research in 2D transition-metal dichalcogenides (TMDs) and their applications in quantum optics.

This session will showcase multimodal imaging techniques, including reflection and time-resolved photoluminescence (TRPL), performed with our high-performance MicroTime 100 microscope. Complementary spectroscopic insights are provided through photoluminescence emission measurements using the FluoTime 300 spectrometer, highlighting the unique characteristics of these advanced materials and their potential in next-generation photonic devices.

Whether you’re a researcher, engineer, or enthusiast in nanophotonics and quantum materials, this webinar will offer valuable insights into the characterization and design of van der Waals materials for quantum optical applications. Don’t miss this opportunity to explore the forefront of 2D material spectroscopy and imaging with a leading expert in the field.

Shengxi Huang
Shengxi Huang

Shengxi Huang is an associate professor in the Department of Electrical and Computer Engineering at Rice University. Huang earned her PhD in electrical engineering and computer science at MIT in 2017, under the supervision of Professors Mildred Dresselhaus and Jing Kong. Following that, she did postdoctoral research at Stanford University with Professors Tony Heinz and Jonathan Fan. She obtained her bachelor’s degree with the highest honors at Tsinghua University, China. Before joining Rice, she was an assistant professor in the Department of Electrical Engineering, Department of Biomedical Engineering, and Materials Research Institute at The Pennsylvania State University.

Huang’s research interests involve light-matter interactions of quantum materials and nanostructures, and the development of new quantum optical platforms and biochemical sensing technologies. In particular, her research focuses on (1) understanding optical and electronic properties of new materials such as 2D materials and Weyl semimetals, (2) developing new biochemical sensing techniques with applications in medical diagnosis, and (3) exploring new quantum optical effects and quantum sensing. She is leading the SCOPE (Sensing, Characterization, and OPtoElectronics) Laboratory.

The post Designer van der Waals materials for quantum optical emission appeared first on Physics World.

Simultaneous two- and three-photon imaging enables rapid cancer diagnosis

7 avril 2025 à 10:30

Multiphoton microscopy is a nonlinear optical imaging technique that enables label-free, damage-free biological imaging. Performed using femtosecond laser pulses to generate two- and three-photon processes, multiphoton imaging techniques could prove invaluable for rapid cancer diagnosis or personalized medicine.

Imaging biological samples with traditional confocal microscopy requires sample slicing and staining to create contrast in the tissue. The nonlinear mechanisms generated by femtosecond laser pulses, however, eliminate the need for labelling or sample preparation, revealing molecular and structural details within tissue and cells while leaving the sample intact.

Looking to bring these benefits to cancer diagnostics, Netherlands-based start-up Flash Pathology is developing a compact, portable multiphoton microscope that creates pathology-quality images in real time, without the need for sample fixation or staining.

Fast and accurate cancer diagnosis with higher harmonic imaging

The inspiration for Flash Pathology came from Marloes Groot of Vrije Universiteit (VU) Amsterdam. While studying multiphoton microscopy of brain tumours, Groot recognized the need for a portable microscope for clinical settings. “This is a really powerful technique,” she says. “I was working on my large laboratory setup and I thought if we start a company, we could transform this into a mobile device.”

Groot teamed up with Frank van Mourik, now Flash Pathology’s CTO, to shrink the imaging device into a compact 60 x 80 x 115 cm system. “Frank made a device that can be transported, in a truck, wheeled through corridors, and still when you plug it in, it’s on and it produces images – for a nonlinear microscope, this is pretty special,” she explains.

Van Mourik has now built several multiphoton microscopes for Flash Pathology, with one of the main achievements the ability to measure samples with extremely low power levels. “When I started in my lab, I used 200 mW of power, but we’ve been able to reduce that to 5 mW,” Groot notes. “We have performed extensive studies to show that our imaging does not affect the tissue.”

Flash Pathology’s multiphoton microscope is designed to provide rapid on-site histologic feedback on excised tissue, such as diagnostic biopsies or tissue from surgical resections. One key application is lung cancer diagnosis, where there is a clinical need for rapid intraoperative feedback on biopsies. The standard histopathological analysis requires extensive sample preparation and can take several days to provide results.

Multiphoton microscopy of adipose tissue, cartilage and lymphatic tissue
Rapid tissue analysis Multiphoton microscopy images of (left to right) adipose tissue, cartilage and lymphoid tissue (each image is 400 x 400 µm). The adipose tissue image shows large adipocytes (fat cells); the cartilage image shows a hyaline (glass-like) background with chondrocytes (cells); the image of lymphoid tissue shows many small lymphocytes (a type of immune cell). (Courtesy: VU Amsterdam)

“With lung biopsies, it’s challenging to obtain good diagnostic material,” explains Sylvia Spies, a PhD student at VU Amsterdam. “The lesions can be quite small and it can be difficult to get to the right position and take a good sample, so they use several techniques (fluoroscopy/CT or ultrasound) to find the right position and take multiple biopsies from the lesion. Despite these techniques, the diagnostic yield is still around 70%, so 30% of cases still don’t get a diagnosis and patients might have to come back for a repeat biopsy procedure.”

Multiphoton imaging, on the other hand, can rapidly visualize unprocessed tissue samples, enabling diagnosis in situ. A recent study using Flash Pathology’s microscope to analyse lung biopsies demonstrated that it could image a biopsy sample and provide feedback just 6 min after excision, with an accuracy of 87% – enabling immediate decisions as to whether a further biopsy is required.

“Also, many clinical fields are now focusing on a one-stop-shop with diagnosis and treatment in one procedure,” adds Spies. “Here, you really need a technique that can rapidly determine whether a lesion is benign or malignant.”

The microscope’s impressive diagnostic performance is partly due to its ability to generate four nonlinear signals simultaneously using a single ultrafast femtosecond laser: second- and third-harmonic generation plus two- and three-photon fluorescence. The system then uses filters to spectrally separate these signals, which provide complementary diagnostic information. Second-harmonic generation, for example, is sensitive to non-centrosymmetric structures such as collagen, while third-harmonic generation only occurs at interfaces with differing refractive indices, such as cell membranes or boundaries between the nucleus and cytoplasm.

“What I like about this technique is that you can see similar features as in conventional histology,” says Spies. “You can see structures such as collagen fibres, elastin fibres and cellular patterns, but also cellular details such as the cytoplasm, the nucleus (and its size), nucleoli and cilia. All these tiny details are the same features that the pathologists look at in conventional histology.”

Applying femtosecond lasers for 3D-in-depth visualization

The femtosecond laser plays a key role in enabling multiphoton microscopy. To excite two- and three-photon processes, you need to have two or more photons in the same place at exactly the same time. And the likelihood of this happening increases rapidly when using ultrashort laser pulses.

“The shorter the pulses are in the time domain, the higher the probability that you have an overlap of two pulses in a focal point,” explains Oliver Prochnow, CEO of VALO Innovations, a part of HÜBNER Photonics. “Therefore you need to have a very high-intensity, extremely short laser pulse. The shorter the better.”

The VALO Femtosecond Series of ultrafast fibre lasers can deliver pulses as short as 30 fs, which is achieved by exploiting nonlinear mechanisms to broaden the spectral bandwidth to more than 100 nm. As the optical spectrum and pulse duration are inherently related by Fourier transformation, a broadband spectrum will result in a very short pulse. And the shorter the pulse, at the same average power, the higher its peak power – and the higher the probability of producing multiphoton processes.

VALO Femtosecond Series laser parameters
Laser parameters Left: typical temporal pulse profile highlighting the sub 50 fs pulse duration with very low pulse pedestal; the inset shows the typical beam profile. Right: typical optical spectrum of HÜBNER Photonics’ VALO Femtosecond Series lasers. (Courtesy: HÜBNER Photonics)

“If you decrease the pulse duration by a factor of five, this gives roughly a five times higher signal from two-photon absorption,” says Prochnow. “In contrast, a three-photon process scales with the third power of the intensity and with the inverse of the pulse duration squared. So you have a roughly 25 times higher signal, if you decrease the pulse duration by a factor of five at the same average power.” Crucially, the shorter pulses deliver this high peak power while maintaining a low average power, reducing sample heating and minimizing photobleaching.

The broadband optical spectrum is particularly important for enabling practical three-photon microscopy. The challenge here is that traditional ytterbium-based lasers with a wavelength of around 1030 nm produce a three-photon signal in the UV range, which is too short to be transmitted through standard optics.

Third-harmonic generation spectra
Broadband spectrum Fundamental and third-harmonic generation (THG) spectra of a 30 fs broadband fibre laser (red) compared with standard 150 fs lasers. The solid black line shows the typical transmission characteristics of a standard microscopy objective. Only a THG spectrum generated from wavelengths of above 1080 nm will be transmitted. (Courtesy: HÜBNER Photonics)

The VALO Femtosecond Series overcomes this problem by having a broadband spectrum that extends up to 1140 nm. Frequency tripling then generates a signal with a long enough wavelength to pass through a standard microscope objective, enabling the VALO lasers to excite both two-photon and three-photon processes. “Our lasers provide the opportunity to perform simultaneous three-photon microscopy and two-photon microscopy using a simple fibre laser solution,” says Prochnow.

The lasers include an integrated dispersion pre-compensation unit to compensate for the dispersion of a microscope objective and provide the shortest pulses at the sample. Additionally, the lasers do not require water cooling, making them easy to use or integrate.

Towards future clinical applications

Flash Pathology is currently testing its microscope in several hospitals in the Netherlands, including Amsterdam UMC, as well as the Princess Maxima Center for paediatric oncology. “Sylvia performed a study in their pathology department and for a year measured all kinds of tissue samples that came through,” says Groot. “We also recently installed a device at the Queen Elizabeth Hospital in Glasgow, for a study on mesothelioma.”

With prototypes now available for research use, the company also plans to develop a fully certified multiphoton microscopy system. “Our ultimate goal is to sell a certified medical diagnostic device that will take a biopsy and produce images, but also contain artificial intelligence to help to interpret the images and give diagnostic conclusions about the nature of the illness,” says van Mourik.

Once fully realised in the clinic, the multiphoton microscopy system will provide an invaluable tool for rapid, in situ tissue analysis during bronchoscopy procedures or other operations. The unique combination of four nonlinear imaging modalities, made possible with a single compact femtosecond laser, delivers complementary diagnostic information. “This will be the big gain, to be able to provide a diagnosis bedside during a procedure,” van Mourik concludes.

 

The post Simultaneous two- and three-photon imaging enables rapid cancer diagnosis appeared first on Physics World.

Joint APS meeting brings together the physics community

12 mars 2025 à 12:05

New for 2025, the American Physical Society (APS) is combining its March Meeting and April Meeting into a joint event known as the APS Global Physics Summit. The largest physics research conference in the world, the Global Physics Summit brings together 14,000 attendees across all disciplines of physics. The meeting takes place in Anaheim, California (as well as virtually) from 16 to 21 March.

Uniting all disciplines of physics in one joint event reflects the increasingly interdisciplinary nature of scientific research and enables everybody to participate in any session. The meeting includes cross-disciplinary sessions and collaborative events, where attendees can meet to connect with others, discuss new ideas and discover groundbreaking physics research.

The meeting will take place in three adjacent venues. The Anaheim Convention Center will host March Meeting sessions, while the April Meeting sessions will be held at the Anaheim Marriott. The Hilton Anaheim will host SPLASHY (soft, polymeric, living, active, statistical, heterogenous and yielding) matter and medical physics sessions. Cross-disciplinary sessions and networking events will take place at all sites and in the connecting outdoor plaza.

With programming aligned with the 2025 International Year of Quantum Science and Technology, the meeting also celebrates all things quantum with a dedicated Quantum Festival. Designed to “inspire and educate”, the festival incorporates events at the intersection of art, science and fun – with multimedia performances, science demonstrations, circus performers, and talks by Nobel laureates and a NASA astronaut.

Finally, there’s the exhibit hall, where more than 200 exhibitors will showcase products and services for the physics community. Here, delegates can also attend poster sessions, a career fair and a graduate school fair. Read on to find out about some of the innovative product offerings on show at the technical exhibition.

Precision motion drives innovative instruments for physics applications

For over 25 years Mad City Labs has provided precision instrumentation for research and industry, including nanopositioning systems, micropositioners, microscope stages and platforms, single-molecule microscopes and atomic force microscopes (AFMs).

This product portfolio, coupled with the company’s expertise in custom design and manufacturing, enables Mad City Labs to provide solutions for nanoscale motion for diverse applications such as astronomy, biophysics, materials science, photonics and quantum sensing.

Mad City Labs’ piezo nanopositioners feature the company’s proprietary PicoQ sensors, which provide ultralow noise and excellent stability to yield sub-nanometre resolution and motion control down to the single picometre level. The performance of the nanopositioners is central to the company’s instrumentation solutions, as well as the diverse applications that it can serve.

Within the scanning probe microscopy solutions, the nanopositioning systems provide true decoupled motion with virtually undetectable out-of-plane movement, while their precision and stability yields high positioning performance and control. Uniquely, Mad City Labs offers both optical deflection AFMs and resonant probe AFM models.

Mad City Labs product portfolio
Product portfolio Mad City Labs provides precision instrumentation for applications ranging from astronomy and biophysics, to materials science, photonics and quantum sensing. (Courtesy: Mad City Labs)

The MadAFM is a sample scanning AFM in a compact, tabletop design. Designed for simple user-led installation, the MadAFM is a multimodal optical deflection AFM and includes software. The resonant probe AFM products include the AFM controllers MadPLL and QS-PLL, which enable users to build their own flexibly configured AFMs using Mad City Labs micro- and nanopositioners. All AFM instruments are ideal for material characterization, but resonant probe AFMs are uniquely well suited for quantum sensing and nano-magnetometry applications.

Stop by the Mad City Labs booth and ask about the new do-it-yourself quantum scanning microscope based on the company’s AFM products.

Mad City Labs also offers standalone micropositioning products such as optical microscope stages, compact positioners and the Mad-Deck XYZ stage platform. These products employ proprietary intelligent control to optimize stability and precision. These micropositioning products are compatible with the high-resolution nanopositioning systems, enabling motion control across micro–picometre length scales.

The new MMP-UHV50 micropositioning system offers 50 mm travel with 190 nm step size and maximum vertical payload of 2 kg, and is constructed entirely from UHV-compatible materials and carefully designed to eliminate sources of virtual leaks. Uniquely, the MMP-UHV50 incorporates a zero power feature when not in motion to minimize heating and drift. Safety features include limit switches and overheat protection, a critical item when operating in vacuum environments.

For advanced microscopy techniques for biophysics, the RM21 single-molecule microscope, featuring the unique MicroMirror TIRF system, offers multicolour total internal-reflection fluorescence microscopy with an excellent signal-to-noise ratio and efficient data collection, along with an array of options to support multiple single-molecule techniques. Finally, new motorized micromirrors enable easier alignment and stored setpoints.

  • Visit Mad City Labs at the APS Global Summit, at booth #401

New lasers target quantum, Raman spectroscopy and life sciences

HÜBNER Photonics, manufacturer of high-performance lasers for advanced imaging, detection and analysis, is highlighting a large range of exciting new laser products at this year’s APS event. With these new lasers, the company responds to market trends specifically within the areas of quantum research and Raman spectroscopy, as well as fluorescence imaging and analysis for life sciences.

Dedicated to the quantum research field, a new series of CW ultralow-noise single-frequency fibre amplifier products – the Ampheia Series lasers – offer output powers of up to 50 W at 1064 nm and 5 W at 532 nm, with an industry-leading low relative intensity noise. The Ampheia Series lasers ensure unmatched stability and accuracy, empowering researchers and engineers to push the boundaries of what’s possible. The lasers are specifically suited for quantum technology research applications such as atom trapping, semiconductor inspection and laser pumping.

Ampheia Series laser from HÜBNER Photonics
Ultralow-noise operation The Ampheia Series lasers are particularly suitable for quantum technology research applications. (Courtesy: HÜBNER Photonics)

In addition to the Ampheia Series, the new Cobolt Qu-T Series of single frequency, tunable lasers addresses atom cooling. With wavelengths of 707, 780 and 813 nm, course tunability of greater than 4 nm, narrow mode-hop free tuning of below 5 GHz, linewidth of below 50 kHz and powers of 500 mW, the Cobolt Qu-T Series is perfect for atom cooling of rubidium, strontium and other atoms used in quantum applications.

For the Raman spectroscopy market, HÜBNER Photonics announces the new Cobolt Disco single-frequency laser with available power of up to 500 mW at 785 nm, in a perfect TEM00 beam. This new wavelength is an extension of the Cobolt 05-01 Series platform, which with excellent wavelength stability, a linewidth of less than 100 kHz and spectral purity better than 70 dB, provides the performance needed for high-resolution, ultralow-frequency Raman spectroscopy measurements.

For life science applications, a number of new wavelengths and higher power levels are available, including 553 nm with 100 mW and 594 nm with 150 mW. These new wavelengths and power levels are available on the Cobolt 06-01 Series of modulated lasers, which offer versatile and advanced modulation performance with perfect linear optical response, true OFF states and stable illumination from the first pulse – for any duty cycles and power levels across all wavelengths.

The company’s unique multi-line laser, Cobolt Skyra, is now available with laser lines covering the full green–orange spectral range, including 594 nm, with up to 100 mW per line. This makes this multi-line laser highly attractive as a compact and convenient illumination source in most bioimaging applications, and now also specifically suitable for excitation of AF594, mCherry, mKate2 and other red fluorescent proteins.

In addition, with the Cobolt Kizomba laser, the company is introducing a new UV wavelength that specifically addresses the flow cytometry market. The Cobolt Kizomba laser offers 349 nm output at 50 mW with the renowned performance and reliability of the Cobolt 05-01 Series lasers.

  • Visit HÜBNER Photonics at the APS Global Summit, at booth #359.

 

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The complex and spatially heterogeneous nature of degradation in heavily cycled Li-ion cells

5 mars 2025 à 11:22

As service lifetimes of electric vehicle (EV) and grid storage batteries continually improve, it has become increasingly important to understand how Li-ion batteries perform after extensive cycling. Using a combination of spatially resolved synchrotron x-ray diffraction and computed tomography, the complex kinetics and spatially heterogeneous behavior of extensively cycled cells can be mapped and characterized under both near-equilibrium and non-equilibrium conditions.

This webinar shows examples of commercial cells with thousands (even tens of thousands) of cycles over many years. The behaviour of such cells can be surprisingly complex and spatially heterogeneous, requiring a different approach to analysis and modelling than what is typically used in the literature. Using this approach, we investigate the long-term behavior of Ni-rich NMC cells and examine ways to prevent degradation. This work also showcases the incredible durability of single-crystal cathodes, which show very little evidence of mechanical or kinetic degradation after more than 20,000 cycles – the equivalent to driving an EV for 8 million km!

Toby Bond
Toby Bond

Toby Bond is a senior scientist in the Industrial Science group at the Canadian Light Source (CLS), Canada’s national synchrotron facility. He is a specialist in x-ray imaging and diffraction, specializing in in-situ and operando analysis of batteries and fuel cells for industry clients of the CLS. Bond is an electrochemist by training, who completed his MSc and PhD in Jeff Dahn’s laboratory at Dalhousie University with a focus in developing methods and instrumentation to characterize long-term degradation in Li-ion batteries.

 

 

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Fermilab’s Anna Grassellino: eyeing the prize of quantum advantage

5 mars 2025 à 11:00

The Superconducting Quantum Materials and Systems (SQMS) Center, led by Fermi National Accelerator Laboratory (Chicago, Illinois), is on a mission “to develop beyond-the-state-of-the-art quantum computers and sensors applying technologies developed for the world’s most advanced particle accelerators”. SQMS director Anna Grassellino talks to Physics World about the evolution of a unique multidisciplinary research hub for quantum science, technology and applications.

What’s the headline take on SQMS?

Established as part of the US National Quantum Initiative (NQI) Act of 2018, SQMS is one of the five National Quantum Information Science Research Centers run by the US Department of Energy (DOE). With funding of $115m through its initial five-year funding cycle (2020-25), SQMS represents a coordinated, at-scale effort – comprising 35 partner institutions – to address pressing scientific and technological challenges for the realization of practical quantum computers and sensors, as well as exploring how novel quantum tools can advance fundamental physics.

Our mission is to tackle one of the biggest cross-cutting challenges in quantum information science: the lifetime of superconducting quantum states – also known as the coherence time (the length of time that a qubit can effectively store and process information). Understanding and mitigating the physical processes that cause decoherence – and, by extension, limit the performance of superconducting qubits – is critical to the realization of practical and useful quantum computers and quantum sensors.

How is the centre delivering versus the vision laid out in the NQI?

SQMS has brought together an outstanding group of researchers who, collectively, have utilized a suite of enabling technologies from Fermilab’s accelerator science programme – and from our network of partners – to realize breakthroughs in qubit chip materials and fabrication processes; design and development of novel quantum devices and architectures; as well as the scale-up of complex quantum systems. Central to this endeavour are superconducting materials, superconducting radiofrequency (SRF) cavities and cryogenic systems – all workhorse technologies for particle accelerators employed in high-energy physics, nuclear physics and materials science.

At the core of SQMS success are top-level scientists and engineers leading the centre’s cutting-edge quantum research programmes
Collective endeavour At the core of SQMS success are top-level scientists and engineers leading the centre’s cutting-edge quantum research programmes. From left to right: Alexander Romanenko, Silvia Zorzetti, Tanay Roy, Yao Lu, Anna Grassellino, Akshay Murthy, Roni Harnik, Hank Lamm, Bianca Giaccone, Mustafa Bal, Sam Posen. (Courtesy: Hannah Brumbaugh/Fermilab)

Take our research on decoherence channels in quantum devices. SQMS has made significant progress in the fundamental science and mitigation of losses in the oxides, interfaces, substrates and metals that underpin high-coherence qubits and quantum processors. These advances – the result of wide-ranging experimental and theoretical investigations by SQMS materials scientists and engineers – led, for example, to the demonstration of transmon qubits (a type of charge qubit exhibiting reduced sensitivity to noise) with systematic improvements in coherence, record-breaking lifetimes of over a millisecond, and reductions in performance variation.

How are you building on these breakthroughs?

First of all, we have worked on technology transfer. By developing novel chip fabrication processes together with quantum computing companies, we have contributed to our industry partners’ results of up to 2.5x improvement in error performance in their superconducting chip-based quantum processors.

We have combined these qubit advances with Fermilab’s ultrahigh-coherence 3D SRF cavities: advancing our efforts to build a cavity-based quantum processor and, in turn, demonstrating the longest-lived superconducting multimode quantum processor unit ever built (coherence times in excess of 20 ms). These systems open the path to a more powerful qudit-based quantum computing approach. (A qudit is a multilevel quantum unit that can be more than two states.) What’s more, SQMS has already put these novel systems to use as quantum sensors within Fermilab’s particle physics programme – probing for the existence of dark-matter candidates, for example, as well as enabling precision measurements and fundamental tests of quantum mechanics.

Elsewhere, we have been pushing early-stage societal impacts of quantum technologies and applications – including the use of quantum computing methods to enhance data analysis in magnetic resonance imaging (MRI). Here, SQMS scientists are working alongside clinical experts at New York University Langone Health to apply quantum techniques to quantitative MRI, an emerging diagnostic modality that could one day provide doctors with a powerful tool for evaluating tissue damage and disease.

What technologies pursued by SQMS will be critical to the scale-up of quantum systems?

There are several important examples, but I will highlight two of specific note. For starters, there’s our R&D effort to efficiently scale millikelvin-regime cryogenic systems. SQMS teams are currently developing technologies for larger and higher-cooling-power dilution refrigerators. We have designed and prototyped novel systems allowing over 20x higher cooling power, a necessary step to enable the scale-up to thousands of superconducting qubits per dilution refrigerator.

Materials insights The SQMS collaboration is studying the origins of decoherence in state-of-the-art qubits (above) using a raft of advanced materials characterization techniques – among them time-of-flight secondary-ion mass spectrometry, cryo electron microscopy and scanning probe microscopy. With a parallel effort in materials modelling, the centre is building a hierarchy of loss mechanisms that is informing how to fabricate the next generation of high-coherence qubits and quantum processors. (Courtesy: Dan Svoboda/Fermilab)

Also, we are working to optimize microwave interconnects with very low energy loss, taking advantage of SQMS expertise in low-loss superconducting resonators and materials in the quantum regime. (Quantum interconnects are critical components for linking devices together to enable scaling to large quantum processors and systems.)

How important are partnerships to the SQMS mission?

Partnerships are foundational to the success of SQMS. The DOE National Quantum Information Science Research Centers were conceived and built as mini-Manhattan projects, bringing together the power of multidisciplinary and multi-institutional groups of experts. SQMS is a leading example of building bridges across the “quantum ecosystem” – with other national and federal laboratories, with academia and industry, and across agency and international boundaries.

In this way, we have scaled up unique capabilities – multidisciplinary know-how, infrastructure and a network of R&D collaborations – to tackle the decoherence challenge and to harvest the power of quantum technologies. A case study in this regard is Ames National Laboratory, a specialist DOE centre for materials science and engineering on the campus of Iowa State University.

Ames is a key player in a coalition of materials science experts – coordinated by SQMS – seeking to unlock fundamental insights about qubit decoherence at the nanoscale. Through Ames, SQMS and its partners get access to powerful analytical tools – modalities like terahertz spectroscopy and cryo transmission electron microscopy – that aren’t routinely found in academia or industry.

How extensive is the SQMS partner network?

All told, SQMS quantum platforms and experiments involve the collective efforts of more than 500 experts from 35 partner organizations, among them the National Institute for Standards and Technology (NIST), NASA Ames Research Center and Northwestern University; also leading companies in the quantum tech industry like IBM and Rigetti Computing. Our network extends internationally and includes flagship tie-ins with the UK’s National Physical Laboratory (NPL), the Institute for Nuclear Physics (INFN) in Italy, and the Institute for Quantum Computing (University of Waterloo, Canada).

What are the drivers for your engagement with the quantum technology industry?

The SQMS strategy for industry engagement is clear: to work hand-in-hand to solve technological challenges utilizing complementary facilities and expertise; to abate critical performance barriers; and to bring bidirectional value. I believe that even large companies do not have the ability to achieve practical quantum computing systems working exclusively on their own. The challenges at hand are vast and often require R&D partnerships among experts across diverse and highly specialized disciplines.

I also believe that DOE National Laboratories – given their depth of expertise and ability to build large-scale and complex scientific instruments – are, and will continue to be, key players in the development and deployment of the first useful and practical quantum computers. This means not only as end-users, but as technology developers. Our vision at SQMS is to lay the foundations of how we are going to build these extraordinary machines in partnership with industry. It’s about learning to work together and leveraging our mutual strengths.

How do Rigetti and IBM, for example, benefit from their engagement with SQMS?

Our collaboration with Rigetti Computing, a Silicon Valley company that’s building quantum computers, has been exemplary throughout: a two-way partnership that leverages the unique enabling technologies within SQMS to boost the performance of Rigetti’s superconducting quantum processors.

The partnership with IBM, although more recent, is equally significant. Together with IBM researchers, we are interested in developing quantum interconnects – including the development of high-Q cables to make them less lossy – for the high-fidelity connection and scale-up of quantum processors into large and useful quantum computing systems.

At the same time, SQMS scientists are exploring simulations of problems in high-energy physics and condensed-matter physics using quantum computing cloud services from Rigetti and IBM.

Presumably, similar benefits accrue to suppliers of ancillary equipment to the SQMS quantum R&D programme?

Correct. We challenge our suppliers of advanced materials and fabrication equipment to go above and beyond, working closely with them on continuous improvement and new product innovation. In this way, for example, our suppliers of silicon and sapphire substrates and nanofabrication platforms – key technologies for advanced quantum circuits – benefit from SQMS materials characterization tools and fundamental physics insights that would simply not be available in isolation. These technologies are still at a stage where we need fundamental science to help define the ideal materials specifications and standards.

We are also working with companies developing quantum control boards and software, collaborating on custom solutions to unique hardware architectures such as the cavity-based qudit platforms in development at Fermilab.

How is your team building capacity to support quantum R&D and technology innovation?

We’ve pursued a twin-track approach to the scaling of SQMS infrastructure. On the one hand, we have augmented – very successfully – a network of pre-existing facilities at Fermilab and at SQMS partners, spanning accelerator technologies, materials science and cryogenic engineering. In aggregate, this covers hundreds of millions of dollars’ worth of infrastructure that we have re-employed or upgraded for studying quantum devices, including access to a host of leading-edge facilities via our R&D partners – for example, microkelvin-regime quantum platforms at Royal Holloway, University of London, and underground quantum testbeds at INFN’s Gran Sasso Laboratory.

Thinking big in quantum The SQMS Quantum Garage (above) houses a suite of R&D testbeds to support granular studies of superconducting qubits, quantum processors, high-coherence quantum sensors and quantum interconnects. (Courtesy: Ryan Postel/Fermilab)

In parallel, we have invested in new and dedicated infrastructure to accelerate our quantum R&D programme. The Quantum Garage here at Fermilab is the centrepiece of this effort: a 560 square-metre laboratory with a fleet of six additional dilution refrigerators for cryogenic cooling of SQMS experiments as well as test, measurement and characterization of superconducting qubits, quantum processors, high-coherence quantum sensors and quantum interconnects.

What is the vision for the future of SQMS?

SQMS is putting together an exciting proposal in response to a DOE call for the next five years of research. Our efforts on coherence will remain paramount. We have come a long way, but the field still needs to make substantial advances in terms of noise reduction of superconducting quantum devices. There’s great momentum and we will continue to build on the discoveries made so far.

We have also demonstrated significant progress regarding our 3D SRF cavity-based quantum computing platform. So much so that we now have a clear vision of how to implement a mid-scale prototype quantum computer with over 50 qudits in the coming years. To get us there, we will be laying out an exciting SQMS quantum computing roadmap by the end of 2025.

It’s equally imperative to address the scalability of quantum systems. Together with industry, we will work to demonstrate practical and economically feasible approaches to be able to scale up to large quantum computing data centres with millions of qubits.

Finally, SQMS scientists will work on exploring early-stage applications of quantum computers, sensors and networks. Technology will drive the science, science will push the technology – a continuous virtuous cycle that I’m certain will lead to plenty more ground-breaking discoveries.

How SQMS is bridging the quantum skills gap

SQMS hosted the inaugural US Quantum Information Science (USQIS) School in summer 2023
Education, education, education SQMS hosted the inaugural US Quantum Information Science (USQIS) School in summer 2023. Held annually, the USQIS is organized in conjunction with other DOE National Laboratories, academia and industry. (Courtesy: Dan Svoboda/Fermilab)

As with its efforts in infrastructure and capacity-building, SQMS is addressing quantum workforce development on multiple fronts.

Across the centre, Grassellino and her management team have recruited upwards of 150 technical staff and early-career researchers over the past five years to accelerate the SQMS R&D effort. “These ‘boots on the ground’ are a mix of PhD students, postdoctoral researchers plus senior research and engineering managers,” she explains.

Another significant initiative was launched in summer 2023, when SQMS hosted nearly 150 delegates at Fermilab for the inaugural US Quantum Information Science (USQIS) School – now an annual event organized in conjunction with other National Laboratories, academia and industry. The long-term goal is to develop the next generation of quantum scientists, engineers and technicians by sharing SQMS know-how and experimental skills in a systematic way.

“The prioritization of quantum education and training is key to sustainable workforce development,” notes Grassellino. With this in mind, she is currently in talks with academic and industry partners about an SQMS-developed master’s degree in quantum engineering. Such a programme would reinforce the centre’s already diverse internship initiatives, with graduate students benefiting from dedicated placements at SQMS and its network partners.

“Wherever possible, we aim to assign our interns with co-supervisors – one from a National Laboratory, say, another from industry,” adds Grassellino. “This ensures the learning experience shapes informed decision-making about future career pathways in quantum science and technology.”

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New transfer arm moves heavier samples in vacuum

26 février 2025 à 13:21

Vacuum technology is routinely used in both scientific research and industrial processes. In physics, high-quality vacuum systems make it possible to study materials under extremely clean and stable conditions. In industry, vacuum is used to lift, position and move objects precisely and reliably. Without these technologies, a great deal of research and development would simply not happen. But for all its advantages, working under vacuum does come with certain challenges. For example, once something is inside a vacuum system, how do you manipulate it without opening the system up?

Heavy duty: The new transfer arm
Heavy duty: The new transfer arm. (Courtesy: UHV Design)

The UK-based firm UHV Design has been working on this problem for over a quarter of a century, developing and manufacturing vacuum manipulation solutions for new research disciplines as well as emerging industrial applications. Its products, which are based on magnetically coupled linear and rotary probes, are widely used at laboratories around the world, in areas ranging from nanoscience to synchrotron and beamline applications. According to engineering director Jonty Eyres, the firm’s latest innovation – a new sample transfer arm released at the beginning of this year – extends this well-established range into new territory.

“The new product is a magnetically coupled probe that allows you to move a sample from point A to point B in a vacuum system,” Eyres explains. “It was designed to have an order of magnitude improvement in terms of both linear and rotary motion thanks to the magnets in it being arranged in a particular way. It is thus able to move and position objects that are much heavier than was previously possible.”

The new sample arm, Eyres explains, is made up of a vacuum “envelope” comprising a welded flange and tube assembly. This assembly has an outer magnet array that magnetically couples to an inner magnet array attached to an output shaft. The output shaft extends beyond the mounting flange and incorporates a support bearing assembly. “Depending on the model, the shafts can either be in one or more axes: they move samples around either linearly, linear/rotary or incorporating a dual axis to actuate a gripper or equivalent elevating plate,” Eyres says.

Continual development, review and improvement

While similar devices are already on the market, Eyres says that the new product has a significantly larger magnetic coupling strength in terms of its linear thrust and rotary torque. These features were developed in close collaboration with customers who expressed a need for arms that could carry heavier payloads and move them with more precision. In particular, Eyres notes that in the original product, the maximum weight that could be placed on the end of the shaft – a parameter that depends on the stiffness of the shaft as well as the magnetic coupling strength – was too small for these customers’ applications.

“From our point of view, it was not so much the magnetic coupling that needed to be reviewed, but the stiffness of the device in terms of the size of the shaft that extends out to the vacuum system,” Eyres explains. “The new arm deflects much less from its original position even with a heavier load and when moving objects over longer distances.”

The new product – a scaled-up version of the original – can move an object with a mass of up to 50 N (5 kg) over an axial stroke of up to 1.5 m. Eyres notes that it also requires minimal maintenance, which is important for moving higher loads. “It is thus targeted to customers who wish to move larger objects around over longer periods of time without having to worry about intervening too often,” he says.

Moving multiple objects

As well as moving larger, single objects, the new arm’s capabilities make it suitable for moving multiple objects at once. “Rather than having one sample go through at a time, we might want to nest three or four samples onto a large plate, which inevitably increases the size of the overall object,” Eyres explains.

Before they created this product, he continues, he and his UHV Design colleagues were not aware of any magnetic coupled solution on the marketplace that enabled users to do this. “As well as being capable of moving heavy samples, our product can also move lighter samples, but with a lot less shaft deflection over the stroke of the product,” he says. “This could be important for researchers, particularly if they are limited in space or if they wish to avoid adding costly supports in their vacuum system.”

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How cathode microstructure impacts solid-state batteries

25 février 2025 à 17:34

Solid-state batteries are considered next-generation energy storage technology as they promise higher energy density and safety than lithium-ion batteries with a liquid electrolyte. However, major obstacles for commercialization are the requirement of high stack pressures as well as insufficient power density. Both aspects are closely related to limitations of charge transport within the composite cathode.

This webinar presents an introduction on how to use electrochemical impedance spectroscopy for the investigation of composite cathode microstructures to identify kinetic bottlenecks. Effective conductivities can be obtained using transmission line models and be used to evaluate the main factors limiting electronic and ionic charge transport.

In combination with high-resolution 3D imaging techniques and electrochemical cell cycling, the crucial role of the cathode microstructure can be revealed, relevant factors influencing the cathode performance identified, and optimization strategies for improved cathode performance.

Philip Minnmann
Philip Minnmann

Philip Minnmann received his M.Sc. in Material from RWTH Aachen University. He later joined Prof. Jürgen Janek’s group at JLU Giessen as part of the BMBF Cluster of Competence for Solid-State Batteries FestBatt. During his Ph.D., he worked on composite cathode characterization for sulfide-based solid-state batteries, as well as processing scalable, slurry-based solid-state batteries. Since 2023, he has been a project manager for high-throughput battery material research at HTE GmbH.

 

Johannes Schubert
Johannes Schubert

Johannes Schubert holds an M.Sc. in Material Science from the Justus-Liebig University Giessen, Germany. He is currently a Ph.D. student in the research group of Prof. Jürgen Janek in Giessen, where he is part of the BMBF Competence Cluster for Solid-State Batteries FestBatt. His main research focuses on characterization and optimization of composite cathodes with sulfide-based solid electrolytes.

The post How cathode microstructure impacts solid-state batteries appeared first on Physics World.

Precision radiosurgery: optimal dose delivery with cobalt-60

24 février 2025 à 16:17
Leksell Gamma Knife Esprit
Leksell Gamma Knife Esprit

Join us for an insightful webinar that delves into the role of Cobalt-60 in intracranial radiosurgery using Leksell Gamma Knife.

Through detailed discussions and expert insights, attendees will learn how Leksell Gamma Knife, powered by cobalt-60, has and continues to revolutionize the field of radiosurgery, offering patients a safe and effective treatment option.

Participants will gain a comprehensive understanding of the use of cobalt in medical applications, highlighting its significance, and learn more about the unique properties of cobalt-60. The webinar will explore the benefits of cobalt-60 in intracranial radiosurgery and why it is an ideal choice for treating brain lesions while minimizing damage to surrounding healthy tissue.

Don’t miss this opportunity to enhance your knowledge and stay at the forefront of medical advancements in radiosurgery!

Riccardo Bevilacqua
Riccardo Bevilacqua

Riccardo Bevilacqua, a nuclear physicist with a PhD in neutron data for Generation IV nuclear reactors from Uppsala University, has worked as a scientist for the European Commission and at various international research facilities. His career has transitioned from research to radiation safety and back to medical physics, the field that first interested him as a student in Italy. Based in Stockholm, Sweden, he leads global radiation safety initiatives at Elekta. Outside of work, Riccardo is a father, a stepfather, and writes popular science articles on physics and radiation.

 

The post Precision radiosurgery: optimal dose delivery with cobalt-60 appeared first on Physics World.

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