Two independent teams in the US have demonstrated the potential of using the optical properties of nanocrystals to create remote sensors that measure tiny forces on tiny length scales. One team is based at Stanford University and used nanocrystals to measure the micronewton-scale forces exerted by a worm as it chewed bacteria. The other team is based at several institutes and used the photon avalanche effect in nanocrystals to measure sub-nanonewton to micronewton forces. The latter technique could potentially be used to study forces involved in processes such as stem cell differentiation.

Remote sensing of forces at small scales is challenging, especially inside living organisms. Optical tweezers cannot make remote measurements inside the body, while fluorophores – molecules that absorb and re-emit light – can measure forces in organisms, but have limited range, problematic stability or, in the case of quantum dots, toxicity. Nanocrystals with optical properties that change when subjected to external forces offer a way forward.

At Stanford, materials scientist Jennifer Dionne led a team that used nanocrystals doped with ytterbium and erbium. When two ytterbium atoms absorb near-infrared photons, they can then transfer energy to a nearby erbium atom. In this excited state, the erbium can either decay directly to its lowest energy state by emitting red light, or become excited to an even higher-energy state that decays by emitting green light. These processes are called upconversion.

Colour change

The ratio of green to red emission depends on the separation between the ytterbium and erbium atoms, and the separation between the erbium atoms – explains Dionne’s PhD student Jason Casar, who is lead author of a paper describing the Stanford research. Forces on the nanocrystal can change these separations and therefore affect that ratio.

The researchers encased their nanocrystals in polystyrene vessels approximately the size of a E coli bacterium. They then mixed the encased nanoparticles with E coli bacteria that were then fed to tiny nematode worms. To extract the nutrients, the worm’s pharynx needs to break open the bacterial cell wall. “The biological question we set out to answer is how much force is the bacterium generating to achieve that breakage?” explains Stanford’s Miriam Goodman.

The researchers shone near-infrared light on the worms, allowing them to monitor the flow of the nanocrystals. By measuring the colour of the emitted light when the particles reached the pharynx, they determined the force it exerted with micronewton-scale precision.

Meanwhile, a collaboration of scientists at Columbia University, Lawrence Berkeley National Laboratory and elsewhere has shown that a process called photon avalanche can be used to measure even smaller forces on nanocrystals. The team’s avalanching nanoparticles (ANPs) are sodium yttrium fluoride nanocrystals doped with thulium – and were discovered by the team in 2021.

The fun starts here

The sensing process uses a laser tuned off-resonance from any transition from the ground state of the ANP. “We’re bathing our particles in 1064 nm light,” explains James Schuck of Columbia University, whose group led the research. “If the intensity is low, that all just blows by. But if, for some reason, you do eventually get some absorption – maybe a non-resonant absorption in which you give up a few phonons…then the fun starts. Our laser is resonant with an excited state transition, so you can absorb another photon.”

This creates a doubly excited state that can decay radiatively directly to the ground state, producing an upconverted photon. Or, it energy can be transferred to a nearby thulium atom, which becomes resonant with the excited state transition and can excite more thulium atoms into resonance with the laser. “That’s the avalanche,” says Schuck; “We find on average you get 30 or 40 of these events – it’s analogous to a chain reaction in nuclear fission.”

Now, Schuck and colleagues have shown that the exact number of photons produced in each avalanche decreases when the nanoparticle experiences compressive force. One reason is that the phonon frequencies are raised as the lattice is compressed, making non-radiatively decay energetically more favourable.

The thulium-doped nanoparticles decay by emitting either red or near infrared photons. As the force increases, the red dims more quickly, causing a change in the colour of the emitted light. These effects allowed the researchers to measure forces from the sub-nanonewton to the micronewton range – at which point the light output from the nanoparticles became too low to detect.

Not just for forces

Schuck and colleagues are now seeking practical applications of their discovery, and not just for measuring forces.

“We’re discovering that this avalanching process is sensitive to a lot of things,” says Schuck. “If we put these particles in a cell and we’re trying to measure a cellular force gradient, but the cell also happened to change its temperature, that would also affect the brightness of our particles, and we would like to be able to differentiate between those things. We think we know how to do that.”

If the technique could be made to work in a living cell, it could be used to measure tiny forces such as those involved in the extra-cellular matrix that dictate stem cell differentiation.

Andries Meijerink of Utrecht University in the Netherlands believes both teams have done important work that is impressive in different ways. Schuck and colleagues for unveiling a fundamentally new force sensing technique and Dionne’s team for demonstrating a remarkable practical application.

However, Meijerink is sceptical that photon avalanching will be useful for sensing in the short term. “It’s a very intricate process,” he says, adding, “There’s a really tricky balance between this first absorption step, which has to be slow and weak, and this resonant absorption”. Nevertheless, he says that researchers are discovering other systems that can avalanche. “I’m convinced that many more systems will be found,” he says.

Both studies are described in Nature. Dionne and colleagues report their results here, and Schuck and colleagues here.

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Novel landmine detectors based on nuclear magnetic resonance (NMR) have passed their first field-trial tests. Built by the Sydney-based company mRead, the devices could speed up the removal of explosives in former war zones. The company tested its prototype detectors in Angola late last year, finding that they could reliably sense explosives buried up to 15 cm underground — the typical depth of a deployed landmine.

Landmines are a problem in many countries recovering from armed conflict. According to NATO, some 110 million landmines are located in 70 countries worldwide including Cambodia and Bosnia despite conflict ending in both nations decades ago. Ukraine is currently the world’s most mine-infested country, making vast swathes of Ukraine’s agricultural land potentially unusable for decades.

Such landmines also continue to kill innocent civilians. According to the Landmine and Cluster Munition Monitor, nearly 2000 people died from landmine incidents in 2023 – double the number compared to 2022 – and a further 3660 were injured. Over 80% of the casualties were civilians, with children accounting for 37% of deaths.

Humanitarian “deminers”, who are trying to remove these explosives, currently inspect suspected minefields with hand-held metal detectors. These devices use magnetic induction coils that respond to the metal components present in landmines. Unfortunately, they react to every random piece of metal and shrapnel in the soil, leading to high rates of false positives.

“It’s not unreasonable with a metal detector to see 100 false alarms for every mine that you clear,” says Matthew Abercrombie, research and development officer at the HALO Trust, a de-mining charity. “Each of these false alarms, you still have to investigate as if it were a mine.” But for every mine excavated, about 50 hours is wasted on excavating false positives, meaning that clearing a single minefield could take months or years.

“Landmines make time stand still,” adds HALO Trust research officer Ronan Shenhav. “They can lie silent and invisible in the ground for decades. Once disturbed they kill and maim civilians, as well as valuable livestock, preventing access to schools, roads, and prime agricultural land.”

Hope for the future

One alternative landmine-detecting technology option is NMR, which is already widely used to look for underground mineral resources and scan for drugs at airports. NMR results in nuclei inside atoms emitting a weak electromagnetic signal in the presence of a strong constant magnetic field and a weak oscillating field. As the frequency of the signal depends on the molecule’s structure, every chemical compound has a specific electromagnetic fingerprint.

The problem with using it to sniff out landmines is pervasive environmental radio noise, with the electromagnetic signal emitted by the excited molecules being 16 orders of magnitude weaker than that used to trigger the effect. Digital radio transmission, electricity generators and industrial infrastructure all produce noise of the same frequency as the one the detectors are listening for. Even thunderstorms trigger such a radio hum that can spread across vast distances.

“It’s easier to listen to the Big Bang at the edge of the Universe,” says Nick Cutmore, chief technology officer at mRead. “Because the signal is so small, every interference stops you. That stopped a lot of practical applications of this technique in the past.” Cutmore is part of a team that has been trying to cut the effects of noise since the early 2000s, eventually finding a way to filter out this persistent crackle through a proprietary sensor design.

MRead’s handheld detectors emit radio pulses at frequencies between 0.5 and 5 MHz, which are much higher than the kilohertz-range frequencies used by conventional metal detectors. The signal elicits the magnetic resonance response in atoms of sodium, potassium and chlorine, which are commonly found in explosives. A sensor inside the detector “listens out” for the particular fingerprint signal, locating a forgotten mine more precisely than is possible with conventional metal detectors.

With over two million landmines laid in Ukraine since 2022, landmine clearance needs to be faster, safer, and smarter

James Cowan

Given that the detected signal is so small, it has be amplified, but this resulted in adding noise. The company says it has found a way to make sure the electronics in the detector do not exacerbate the problem. “Our current handheld system only consumes 40 to 50 W when operating,” says Cutmore. “Previous systems have sometimes operated at a few kilowatts, making them power-hungry and bulky.”

Having tested the prototype detectors in a simulated minefield in Australia in August 2024, mRead engineers have now deployed them in minefields in Angola in cooperation with the HALO Trust. As the detectors respond directly to the explosive substance, they almost eliminated false positives completely, allowing deminers to double-check locations flagged by metal detectors before time-consuming digging took place.

During the three-week trial, the researchers also detected mines that had a low content of metal, which is difficult to spot with metal detectors.“Instead of doing 1000 metal detections and finding one mine, we can isolate those detections and very quickly before people start digging,” says Cutmore.

Researchers at mRead plan to return to Angola later this year for further tests. They also want to finetune their prototypes and begin working on devices that could be produced commercially. “I am tremendously excited by the results of these trials,” says James Cowan, chief executive officer of the HALO Trust. “With over two million landmines laid in Ukraine since 2022, landmine clearance needs to be faster, safer, and smarter.”

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Whether creating a contaminant-free environment for depositing material or minimizing unwanted collisions in spectrometers and accelerators, vacuum environments are a crucial element of many scientific endeavours. Creating and maintaining very low pressures requires a holistic approach to system design that includes material selection, preparation, and optimization of the vacuum chamber and connection volumes. Measurement strategies also need to be considered across the full range of vacuum to ensure consistent performance and deliver the expected outcomes from the experiment or process.

Developing a vacuum system that achieves the optimal low-pressure conditions for each application, while also controlling the cost and footprint of the system, is a complex balancing act that benefits from specialized expertise in vacuum science and engineering. A committed technology partner with extensive experience of working with customers to design vacuum systems, including those for physics research, can help to define the optimum technologies that will produce the best solution for each application.

Over many years, the technology experts at Agilent have assisted countless customers with configuring and enhancing their vacuum processes. “Our best successes come from collaborations where we take the time to understand the customer’s needs, offer them guidance, and work together to create innovative solutions,” comments John Screech, senior applications engineer at Agilent. “We strive to be a trusted partner rather than just a commercial vendor, ensuring our customers not only have the right tools for their needs, but also the information they need to achieve their goals.”

In his role Screech works with customers from the initial design phase all the way through to installation and troubleshooting. “Many of our customers know they need vacuum, but they don’t have the time or resources to really understand the individual components and how they should be put together,” he says. “We are available to provide full support to help customers create a complete system that performs reliably and meets the requirements of their application.”

In one instance, Screech was able to assist a customer who had been using an older technology to create an ultrahigh vacuum environment. “Their system was able to produce the vacuum they needed, but it was unreliable and difficult to operate,” he remembers. By identifying the problem and supporting the migration to a modern, simpler technology, Screech helped his customer to achieve the required vacuum conditions improve uptime and increase throughput.

Agilent collaborates with various systems integrators to create custom vacuum solutions for scientific instruments and processes. Such customized designs must be compact enough to be integrated within the system, while also delivering the required vacuum performance at a cost-effective price point. “Customers trust us to find a practical and reliable solution, and realize that we will be a committed partner over the long term,” says Screech.

Expert partnership yields success

The company also partners with leading space agencies and particle physics laboratories to create customized vacuum solutions for the most demanding applications. For many years, Agilent has supplied high-performance vacuum pumps to CERN, which created the world’s largest vacuum system to prevent unwanted collisions between accelerated particles and residual gas molecules in the Large Hadron Collider.

When engineering a vacuum solution that meets the exact specifications of the facility, one key consideration is the physical footprint of the equipment. Another is ensuring that the required pumping performance is achieved without introducing any unwanted effects – such as stray magnetic fields – into the highly controlled environment. Agilent vacuum experts have the experience and knowledge to engineer innovative solutions that meet such a complex set of criteria. “These large organizations already have highly skilled vacuum engineers who understand the unique parameters of their system, but even they can benefit from our expertise to transform their requirements into a workable solution,” says Screech.

Agilent also shares its knowledge and experience through various educational opportunities in vacuum technologies, including online webinars and dedicated training courses. The practical aspects of vacuum can be challenging to learn online, so in-person classes emphasize a hands-on approach that allows participants to assemble and characterize rough- and high-vacuum systems. “In our live sessions everyone has the opportunity to bolt a system together, test which configuration will pump down faster, and gain insights into leak detection,” says Screech. “We have students from industry and academia in the classes, and they are always able to share tips and techniques with one another.” Additionally, the company maintains a vacuum community as an online resource, where questions can be posed to experts, and collaboration among users is encouraged.

Agilent recognizes that vacuum is an enabler for scientific research and that creating the ideal vacuum system can be challenging. “Customers can trust Agilent as a technology partner,” says Screech. “We can share our experience and help them create the optimal vacuum system for their needs.”

• A new webinar from Agilent, Vacuum for Physics Research, can now be viewed on demand via physicsworld.com. Further resources are available through the Agilent vacuum webinar library, or contact vacuum_training@agilent.com for more information about education and training opportunities.
• You can learn more about vacuum and leak detection technologies from Agilent through the company’s website. Alternatively, visit the partnership webpage to chat with an expert, find training, and explore the benefits of partnering with Agilent.

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