The Keychron M5 Brings Gaming-Level Specs to an Ergonomic Mouse With Varying Success

An ergonomic mouse has always been intimidating – adjusting to the shape and size has kept me from taking the plunge, even if wrist pain is my middle name and I know it’d be “good” for me. However, the Keychron M5 ergonomic mouse may have just turned me into a convert for this function and form. While the verticality of the M5 matches what you’d expect from many of the ergonomic mice on the market, its specs compete with any top-of-the-line gaming mouse. With an 8,000Hz polling rate, a 30,000 DPI sensor, and PTFE feet for easy gliding across surfaces, Keychron bridges the gap between ergonomic design and high-end gaming specs. But does this mashup make a meaningful difference in the experience? The answer is complex.
Keychron M5 – Design and Features
The M5 ergonomic mouse has five buttons and two scroll wheels that can be independently programmed using the Keychron Launcher app. The primary button surface is tilted over at a 47° angle and that’s how it’s able to provide optimal ergonomic comfort according to Keychron. And after using it for a couple of weeks, I can vouch for that assertion.
With this being a viable workday mouse, you’ll get some extra mileage out of it if you have the space to carry it, which I did on a recent trip. Of course it’s less than practical to pull out on a plane or at an event space, but it does help to have it on hand while working away from your usual set-up. And the battery life is the real show-stealer, lasting upward of 140 hours under ideal conditions – it’s one way that we see the M5’s versatility show up when it comes to mice. But how well the switches on the left and right buttons hold up is another highlight; while I wouldn’t usually try to take such a large mouse on the go, the Huano 80M micro-switches have a satisfying click that puts typical non-gaming mice to shame.
With all of its pluses, the one larger hiccup with the mouse is that at its size, my hands may be just too small to fully use the left side button features beyond the side scrolling feature. The M5 is definitely suited for those with larger hands. When I remembered the sideways scroll wheel was there, it was useful particularly when it comes to productivity during work tasks, but its positioning made it less than ideal to use naturally. Transitioning to an ergonomic mouse did take some time for me, but the right side of the mouse was much easier to adjust to thanks to how well my hand gelled with its button placement. Ultimately, while it’s hard to hold it against the mouse’s design, my smaller hands meant some of its features weren’t as intuitive to use as I’d hoped.
The M5 can be used wirelessly via 2.4 GHz with its USB-C dongle and through Bluetooth connection, and it works just fine when connected to devices with the packaged USB-C cable. It comes with an adapter for those with computers lacking the USB-C ports as well. You even get a 2.4GHz extension hub for those with more complex setups, letting you have a clean signal for the mouse. The only issue I encountered was actually syncing the M5 with my hardware’s Bluetooth which meant that the dongle was necessary to keep on me. Unlike a lot of wireless mice, the M5 doesn’t have a feature that allows you to store the dongle inside the mouse itself meaning it was a crapshoot as to whether or not I’d lose the dongle while traveling (which is okay, that’s on me). But when wireless usage is a feature, thinking about the lifestyle that takes a value in that does make you think about storage.
There are six polling rate settings going all the way up to the high-performance 8,000Hz, which you only see on the top-performing gaming mice. (If you’re unfamiliar, a mouse’s polling rate is how frequently it reports its position to the computer it’s connected to. It’s not necessarily about input delay when using wireless products, but rather how smooth your mouse movements will be tracked.) This is accessible in both the 2.4 GHz wireless dongle and wired USB-C connection, and the kicker here is that the M5 doesn’t need the launcher to adjust the polling rates. You’ll see different buttons located on the mouse’s underside that allow you to adjust the DPI and polling rate as denoted by different colored positional lights. You can manually adjust this by clicking the buttons and moving the light position to align with different settings. Once I realized that I was trying to move the mouse more than needed and figured out the right level of sensitivity, I stopped needing to over-adjust my movements in game.
Keychron M5 – Software and Customization
Setting up the M5 is one of the easiest experiences I’ve had personalizing a gaming peripheral. While most mice, headsets, mics, keyboards, and the like all require downloading individual apps to customize RGB lighting, sensitivity, and their suite of options, Keychron doesn’t. Instead, the Keychron Launcher is a browser app that allows you to customize your device immediately (as we covered in the Keychron K4 HE keyboard, for example). The difference from its competitors is that there is no standalone app to download to each new device to adjust the mouse to your needs at the time, and this browser-based app can be accessed from any device with internet access and is supported by all modern operating systems.
Throughout the review period I used the M5 Ergonomic mouse on three different machines. While all of them were Windows-based PCs, they varied in device-type – from a basic Surface tablet-laptop to a gaming laptop and a gaming PC, and each time I went to the Keychron launcher and had easy access to adjust my settings. I wish all devices would adopt options like this because getting connected is simple and it also immediately allows you to keep your firmware updated immediately without having to run update checks.
Keychron M5 – Performance
When it comes to moment-to-moment use, the M5 is extremely good with its accurate tracking as there was next to no input lag when handling fast-paced games. The amount of control you get in its feature set really lets you determine how much physical exertion you want to put in for normal tasks. That said, it does take quite some time to get used to if you haven’t used a “tall” mouse before, but after taking the time to make the adjustment, the mouse stops being something quirky and starts being a peripheral that I was moving from both my workstation and personal devices.
However, the M5 doesn’t exactly pass the gaming test for me. When it comes to movement, the added weight is a little more difficult to make more drastic and quick swipes you’d need to in certain games – the PTFE mouse feet helped make for the sometimes cumbersome size, helping it glide easily. This makes customization for sensitivity settings including DPI even more important in order to help offset things. Finessing the right settings to come up with your ideal profile for the M5 is a process that will take time.
During the review period, I used the M5 while playing Two Point Museum and Final Fantasy XIV, as well as a couple of matches of Marvel Rivals. Across the three different game types, nothing really felt like a great fit for the M5. Granted, I tend to use a traditional mouse so getting familiar with the ergonomic design was part of the process, and pinpointing its practicality for gaming is challenging (and makes the inclusion of a high-performance 8,000Hz polling rate more curious). But the story is much different when using the M5 for all of my work tasks.

Most days, I work editing Notion pages, adjusting cards in Kanban boards, and managing data sets in spreadsheets. All of these little tasks require a lot of mouse clicks, and most of the time, my compact mouse wound up leaving my hand feeling more cramped than anything, depending on how much time I’m spending organizing spreadsheets. With the ergonomic mouse design really getting its shine when it comes to productivity and work environments, this shouldn’t be a surprise yet it speaks to how the M5 nails this aspect.
As I moved the M5 between my personal workstation and my gaming PC, I tried to work it into my gaming routine. Still, the comfort it provided wasn’t worth the more cumbersome design elements for gaming, and ultimately, an ergonomic, lightweight controller will remain in my rotation, especially for when I have arthritis flare-ups. But for work? The M5 is going to be a staple and has made me a convert to its form and function. It doesn’t look as sleek as my tiny, aesthetically pleasing Logitech G705, but it felt substantially better as the day wore on.
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The real winner for the M5 is its 140-hour battery life. I tried my hardest to keep the mouse active and working as much as I could to wear out the battery in testing – however, it should be said that I used the mouse primarily in Bluetooth mode and not in the standard 1,000Hz polling rate via 2.4GHz wireless for most of the time, as Keychron does denote a difference of about 20 hours between the two modes. But I’m pleased to say that Keychron’s M5 just wouldn’t die, and it’s actually still not dead (though I did connect it to my PC to briefly test its wired performance).