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Could egg defect breakthrough help stop the ‘horrible IVF rollercoaster’?

Results of research offer hope to older women – but it will be several years at least before technique is approved

It is a rollercoaster of emotional extremes that will be familiar to many who have gone through IVF treatment: hope and joy turns to despair and back again. This is especially true for women over 35, the age when IVF success rates decline steeply and for whom the only real way to improve the odds is to keep trying.

While there has been huge progress in IVF in the past decades, including the advent of genetic testing, egg freezing and techniques to overcome male infertility, the primary cause of age-related female infertility – egg quality – has not been directly addressed.

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© Photograph: Maxx-Studio/Shutterstock

© Photograph: Maxx-Studio/Shutterstock

© Photograph: Maxx-Studio/Shutterstock

Human eggs ‘rejuvenated’ in an advance that could boost IVF success rates

Exclusive: Research suggests supplementing eggs with a key protein reduces age-related defects, raising hopes of improved IVF for older women

Scientists claim to have “rejuvenated” human eggs for the first time in an advance that they predict could revolutionise IVF success rates for older women.

The groundbreaking research suggests that an age-related defect that causes genetic errors in embryos could be reversed by supplementing eggs with a crucial protein. When eggs donated by fertility patients were given microinjections of the protein, they were almost half as likely to show the defect compared with untreated eggs.

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© Photograph: David Gregs/Alamy

© Photograph: David Gregs/Alamy

© Photograph: David Gregs/Alamy

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